Ewart, Lorna

Reproducing human and cross-species drug toxicities using a liver-chip

Jang, K.-J., Otieno, M. A., Ronxhi, J., Lim, H.-K., Ewart, L., Kodella, K. R., Petropolis, D. B., Kulkarni, G., Rubins, J. E., Conegliano, D., et al. (2019) · Science Translational Medicine

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 511

Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology

Ewart, L., Apostolou, A., Briggs, S. A., Carman, C. V., Chaff, J. T., Heng, A. R., Jadalannagari, S., Janardhanan, J., Jang, K.-J., Joshipura, S. R., et al. (2022) · Communications Medicine

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 337

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Bauer, S., Wennberg Huldt, C., Kanebratt, K. P., Durieux, I., Gunne, D., Andersson, S., Ewart, L., Haynes, W. G., Maschmeyer, I., Winter, A., et al. (2017) · Scientific Reports

Pancreatic function and diabetes3D Printing in Biomedical Research

Cited by 272

Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid

Foster, A. J., Chouhan, B., Regan, S. L., Rollison, H., Amberntsson, S., Andersson, L. C., Srivastava, A., Darnell, M., Cairns, J., Lazic, S. E., et al. (2019) · Archives of Toxicology

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 117

The Concordance between Nonclinical and Phase I Clinical Cardiovascular Assessment from a Cross-Company Data Sharing Initiative

Ewart, L., Aylott, M., Deurinck, M., Engwall, M., Gallacher, D. J., Geys, H., Jarvis, P., Ju, H., Leishman, D., Leong, L., et al. (2014) · Toxicological Sciences

Animal testing and alternativesCardiac electrophysiology and arrhythmias

Cited by 77

Assessing the predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trials

Mead, A. N., Amouzadeh, H. R., Chapman, K., Ewart, L., Giarola, A., Jackson, S. J., Jarvis, P., Jordaan, P., Redfern, W., Traebert, M., et al. (2016) · Regulatory Toxicology and Pharmacology

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 67

Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective

Ainslie, G. R., Davis, M., Ewart, L., Lieberman, L. A., Rowlands, D. J., Thorley, A. J., Yoder, G., & Ryan, A. M. (2019) · Lab on a Chip

3D Printing in Biomedical ResearchAnimal testing and alternatives

Cited by 65

Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system

Kostrzewski, T., Snow, S., Battle, A. L., Peel, S., Ahmad, Z., Basak, J., Surakala, M., Bornot, A., Lindgren, J., Ryaboshapkina, M., et al. (2021) · Communications Biology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 52