Griffin, Patrick R.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V.-J. A., Novick, S. J., et al. (2018) · Cell

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 638

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

Solt, L. A., Kumar, N., Nuhant, P., Wang, Y., Lauer, J. L., Liu, J., Istrate, M. A., Kamenecka, T. M., Roush, W. R., Vidović, D., et al. (2011) · Nature

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 508

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

Kirschke, E., Goswami, D., Southworth, D., Griffin, P. R., & Agard, D. A. (2014) · Cell

Heat shock proteins researchProtein Structure and Dynamics

Cited by 399

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d

Zhang, C., Konermann, S., Brideau, N. J., Lotfy, P., Wu, X., Novick, S. J., Strutzenberg, T., Griffin, P. R., Hsu, P. D., & Lyumkis, D. (2018) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 276

The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

Long, J. Z., Svensson, K. J., Bateman, L. A., Lin, H., Kamenecka, T., Lokurkar, I. A., Lou, J., Rao, R. R., Chang, M. R., Jedrychowski, M. P., et al. (2016) · Cell

Adipose Tissue and MetabolismLipid metabolism and biosynthesis

Cited by 257

Molecular glue CELMoD compounds are regulators of cereblon conformation

Watson, E. R., Novick, S., Matyskiela, M. E., Chamberlain, P. P., H. de la Peña, A., Zhu, J., Tran, E., Griffin, P. R., Wertz, I. E., & Lander, G. C. (2022) · Science

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 208

An alternate binding site for PPARγ ligands

Hughes, T. S., Giri, P. K., de Vera, I. M. S., Marciano, D. P., Kuruvilla, D. S., Shin, Y., Blayo, A.-L., Kamenecka, T. M., Burris, T. P., Griffin, P. R., et al. (2014) · Nature Communications

Peroxisome Proliferator-Activated ReceptorsNuclear Receptors and Signaling

Cited by 198

Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1

Wang, Y., Lonard, D. M., Yu, Y., Chow, D.-C., Palzkill, T. G., Wang, J., Qi, R., Matzuk, A. J., Song, X., Madoux, F., et al. (2014) · Cancer Research

Phytochemistry and Bioactive CompoundsNatural Compounds in Disease Treatment

Cited by 168

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

Brust, R., Shang, J., Fuhrmann, J., Mosure, S. A., Bass, J., Cano, A., Heidari, Z., Chrisman, I. M., Nemetchek, M. D., Blayo, A.-L., et al. (2018) · Nature Communications

Peroxisome Proliferator-Activated ReceptorsReceptor Mechanisms and Signaling

Cited by 94

Activation of JNK3α1 Requires both MKK4 and MKK7: Kinetic Characterization of in Vitro Phosphorylated JNK3α1

Lisnock, J., Griffin, P., Calaycay, J., Frantz, B., Parsons, J., O'Keefe, S. J., & LoGrasso, P. (2000) · Biochemistry

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 79

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

Feng, L., Dharmarajan, V., Serrao, E., Hoyte, A., Larue, R. C., Slaughter, A., Sharma, A., Plumb, M. R., Kessl, J. J., Fuchs, J. R., et al. (2016) · ACS Chemical Biology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 37

A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

Shkriabai, N., Dharmarajan, V., Slaughter, A., Kessl, J. J., Larue, R. C., Feng, L., Fuchs, J. R., Griffin, P. R., & Kvaratskhelia, M. (2014) · Journal of Biological Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 30

MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma

Kenchappa, R. S., Radnai, L., Young, E. J., Zarco, N., Lin, L., Dovas, A., Meyer, C. T., Haddock, A., Hall, A., Toth, K., et al. (2025) · Cell

Glioma Diagnosis and TreatmentCancer, Hypoxia, and Metabolism

Cited by 21

Structural insights into IMP2 dimerization and RNA binding

Zorc, S. A., Munoz-Tello, P., O’Leary, T., Yu, X., Karadi Giridhar, M. N., Hondros, A. D., Hansel-Harris, A., Forli, S., Griffin, P. R., Kojetin, D. J., et al. (2025) · Journal of Structural Biology

Protein Structure and DynamicsRNA Research and Splicing

Cited by 5

Structural insights into IMP2 dimerization and RNA binding

Zorc, S., Munoz-Tello, P., O'Leary, T., Yu, X., Nag, M., Hansel-Harris, A., Forli, S., Griffin, P. R., Kojetin, D. J., Roy, R. N., et al. (2024) · Journal of Structural Biology

Protein Structure and DynamicsRNA Research and Splicing

Cited by 5