Crouch, Robert J.

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

Nowotny, M., Gaidamakov, S. A., Crouch, R. J., & Yang, W. (2005) · Cell

Enzyme Structure and FunctionDNA and Nucleic Acid Chemistry

Cited by 620

Structure of ribonuclease H phased at 2 a resolution by MAD analysis of the selenomethionyl protein

Yang, W., Hendrickson, W. A., Crouch, R. J., & Satow, Y. (1990) · Science

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 473

Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice

Cerritelli, S. M., Frolova, E. G., Feng, C., Grinberg, A., Love, P. E., & Crouch, R. J. (2003) · Molecular Cell

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 358

RNase H2-Initiated Ribonucleotide Excision Repair

Sparks, J. L., Chon, H., Cerritelli, S. M., Kunkel, T. A., Johansson, E., Crouch, R. J., & Burgers, P. M. (2012) · Molecular Cell

DNA Repair MechanismsFungal and yeast genetics research

Cited by 339

Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription

Nowotny, M., Gaidamakov, S. A., Ghirlando, R., Cerritelli, S. M., Crouch, R. J., & Yang, W. (2007) · Molecular Cell

Enzyme Structure and FunctionHIV/AIDS drug development and treatment

Cited by 316

RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

Pokatayev, V., Hasin, N., Chon, H., Cerritelli, S. M., Sakhuja, K., Ward, J. M., Morris, H. D., Yan, N., & Crouch, R. J. (2016) · Journal of Experimental Medicine

interferon and immune responsesImmunodeficiency and Autoimmune Disorders

Cited by 245

Degradation of DNA RNA Hybrids by Ribonuclease H and DNA Polymerases of Cellular and Viral Origin

Keller, W., & Crouch, R. (1972) · Proceedings of the National Academy of Sciences

DNA and Nucleic Acid ChemistryBiochemical and Molecular Research

Cited by 222

DNA sequence of the gene coding for Escherichia coli ribonuclease H

Kanaya, S., & Crouch, R. J. (1983) · Journal of Biological Chemistry

Bacterial Genetics and BiotechnologyDNA Repair Mechanisms

Cited by 169

Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage

Rychlik, M. P., Chon, H., Cerritelli, S. M., Klimek, P., Crouch, R. J., & Nowotny, M. (2010) · Molecular Cell

Enzyme Structure and FunctionDNA and Nucleic Acid Chemistry

Cited by 109

Isolation of RNase H Genes That Are Essential for Growth of Bacillus subtilis 168

Itaya, M., Omori, A., Kanaya, S., Crouch, R. J., Tanaka, T., & Kondo, K. (1999) · Journal of Bacteriology

Bacterial Genetics and BiotechnologyDNA Repair Mechanisms

Cited by 89

Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2

Malfatti, M. C., Balachander, S., Antoniali, G., Koh, K. D., Saint-Pierre, C., Gasparutto, D., Chon, H., Crouch, R. J., Storici, F., & Tell, G. (2017) · Nucleic Acids Research

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 59

Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development

Uehara, R., Cerritelli, S. M., Hasin, N., Sakhuja, K., London, M., Iranzo, J., Chon, H., Grinberg, A., & Crouch, R. J. (2018) · Cell Reports

DNA Repair MechanismsRNA regulation and disease

Cited by 52

Unlike the Escherichia coli counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA

Malfatti, M. C., Henneke, G., Balachander, S., Koh, K. D., Newnam, G., Uehara, R., Crouch, R. J., Storici, F., & Tell, G. (2019) · Journal of Biological Chemistry

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 17