Myllyharju, Johanna

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

Hirsilä, M., Koivunen, P., Günzler, V., Kivirikko, K. I., & Myllyharju, J. (2003) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 794

Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates

Koivunen, P., Hirsilä, M., Remes, A. M., Hassinen, I. E., Kivirikko, K. I., & Myllyharju, J. (2007) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 521

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

Koivunen, P., Hirsilä, M., Günzler, V., Kivirikko, K. I., & Myllyharju, J. (2004) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 447

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

Köditz, J., Nesper, J., Wottawa, M., Stiehl, D. P., Camenisch, G., Franke, C., Myllyharju, J., Wenger, R. H., & Katschinski, D. M. (2007) · Blood

Endoplasmic Reticulum Stress and DiseaseCancer, Hypoxia, and Metabolism

Cited by 214

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

Heikkilä, M., Pasanen, A., Kivirikko, K. I., & Myllyharju, J. (2011) · Cellular and Molecular Life Sciences

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 213

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

Koivunen, P., Hirsilä, M., Kivirikko, K. I., & Myllyharju, J. (2006) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 129

A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin

Tolonen, J.-P., Heikkilä, M., Malinen, M., Lee, H.-M., Palvimo, J. J., Wei, G.-H., & Myllyharju, J. (2020) · Cellular and Molecular Life Sciences

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 63

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis

Laitala, A., Aro, E., Walkinshaw, G., Mäki, J. M., Rossi, M., Heikkilä, M., Savolainen, E.-R., Arend, M., Kivirikko, K. I., Koivunen, P., et al. (2012) · Blood

Erythropoietin and Anemia TreatmentIron Metabolism and Disorders

Cited by 58