Zhai, Peiyong

Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart

Alcendor, R. R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., Tian, B., Wagner, T., Vatner, S. F., & Sadoshima, J. (2007) · Circulation Research

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 1,147

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D., & Sadoshima, J. (2010) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 772

Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress

Ikeda, Y., Shirakabe, A., Maejima, Y., Zhai, P., Sciarretta, S., Toli, J., Nomura, M., Mihara, K., Egashira, K., Ohishi, M., et al. (2015) · Circulation Research

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 571

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

Maejima, Y., Kyoi, S., Zhai, P., Liu, T., Li, H., Ivessa, A., Sciarretta, S., Del Re, D. P., Zablocki, D. K., Hsu, C.-P., et al. (2013) · Nature Medicine

Autophagy in Disease and TherapyCell death mechanisms and regulation

Cited by 499

Mitophagy is essential for maintaining cardiac function during high fat diet-induced diabetic cardiomyopathy

Tong, M., Saito, T., Zhai, P., Oka, S.-I., Mizushima, W., Nakamura, M., Ikeda, S., Shirakabe, A., & Sadoshima, J. (2019) · Circulation Research

Autophagy in Disease and TherapyCardiovascular Function and Risk Factors

Cited by 498

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

Yamamoto, T., Byun, J., Zhai, P., Ikeda, Y., Oka, S., & Sadoshima, J. (2014) · PLoS ONE

Cardiac Ischemia and ReperfusionSirtuins and Resveratrol in Medicine

Cited by 305

Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia: Pathophysiological Implications in Obesity and Metabolic Syndrome

Sciarretta, S., Zhai, P., Shao, D., Maejima, Y., Robbins, J., Volpe, M., Condorelli, G., & Sadoshima, J. (2012) · Circulation

Autophagy in Disease and TherapyCardiac Ischemia and Reperfusion

Cited by 292

A redox-dependent mechanism for regulation of AMPK activation by thioredoxin1 during energy starvation

Shao, D., Oka, S.-I., Liu, T., Zhai, P., Ago, T., Sciarretta, S., Li, H., & Sadoshima, J. (2014) · Cell Metabolism

Metabolism, Diabetes, and CancerRedox biology and oxidative stress

Cited by 252

Yes-associated Protein Isoform 1 (Yap1) Promotes Cardiomyocyte Survival and Growth to Protect against Myocardial Ischemic Injury

Del Re, D. P., Yang, Y., Nakano, N., Cho, J., Zhai, P., Yamamoto, T., Zhang, N., Yabuta, N., Nojima, H., Pan, D., et al. (2013) · Journal of Biological Chemistry

Congenital heart defects researchHippo pathway signaling and YAP/TAZ

Cited by 249

Differential Roles of GSK-3β During Myocardial Ischemia and Ischemia/Reperfusion

Zhai, P., Sciarretta, S., Galeotti, J., Volpe, M., & Sadoshima, J. (2011) · Circulation Research

Cardiac Ischemia and ReperfusionAutophagy in Disease and Therapy

Cited by 218

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

Matsushima, S., Kuroda, J., Ago, T., Zhai, P., Park, J. Y., Xie, L.-H., Tian, B., & Sadoshima, J. (2013) · Circulation Research

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 183

Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury

Nah, J., Zhai, P., Huang, C.-Y., Fernández, Á. F., Mareedu, S., Levine, B., & Sadoshima, J. (2020) · Journal of Clinical Investigation

Autophagy in Disease and TherapyCardiac Ischemia and Reperfusion

Cited by 150

Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition

Francisco, J., Zhang, Y., Jeong, J. I., Mizushima, W., Ikeda, S., Ivessa, A., Oka, S., Zhai, P., Tallquist, M. D., & Del Re, D. P. (2020) · JACC: Basic to Translational Science

Cardiac Fibrosis and RemodelingHippo pathway signaling and YAP/TAZ

Cited by 133

Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury

Cao, Y., Bojjireddy, N., Kim, M., Li, T., Zhai, P., Nagarajan, N., Sadoshima, J., Palmiter, R. D., & Tian, R. (2017) · Circulation Research

Cardiac Ischemia and ReperfusionMetabolism, Diabetes, and Cancer

Cited by 74