Chou, Kang-Jye

Abstract 526: RMC-9805, a first-in-class, mutant-selective, covalent and oral KRASG12D(ON) inhibitor that induces apoptosis and drives tumor regression in preclinical models of KRASG12D cancers

Jiang, L., Menard, M., Weller, C., Wang, Z., Burnett, L., Aronchik, I., Steele, S., Flagella, M., Zhao, R., Evans, J. W. W., et al. (2023) · Cancer Research

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 76

Abstract 3595: RMC-6291, a next-generation tri-complex KRASG12C(ON) inhibitor, outperforms KRASG12C(OFF) inhibitors in preclinical models of KRASG12C cancers

Nichols, R. J., Yang, Y. C., Cregg, J., Schulze, C. J., Wang, Z., Dua, R., Jiang, J., Garrenton, L. S., Nasholm, N., Bermingham, A., et al. (2022) · Cancer Research

Protein Kinase Regulation and GTPase SignalingLung Cancer Treatments and Mutations

Cited by 37

Abstract 3596: RM-036, a first-in-class, orally-bioavailable, Tri-Complex covalent KRASG12D(ON) inhibitor, drives profound anti-tumor activity in KRASG12D mutant tumor models

Knox, J. E., Jiang, J., Burnett, G. L., Liu, Y., Weller, C. E., Wang, Z., McDowell, L., Steele, S. L., Chin, S., Chou, K. J., et al. (2022) · Cancer Research

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 34

Abstract 1260: First-in-class, orally bioavailable KRASG12V(ON) tri-complex inhibitors, as single agents and in combinations, drive profound anti-tumor activity in preclinical models of KRASG12V mutant cancers

Koltun, E., Cregg, J., Rice, M. A., Whalen, D. M., Freilich, R., Jiang, J., Hansen, R., Bermingham, A., Knox, J. E., Dinglasan, J., et al. (2021) · Cancer Research

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 33

Abstract 1261: A next generation tri-complex KRASG12C(ON) inhibitor directly targets the active, GTP-bound state of mutant RAS and may overcome resistance to KRASG12C(OFF) inhibition

Nichols, R. J., Cregg, J., Schulze, C. J., Wang, Z., Yang, K., Jiang, J., Whalen, D. M., Hansen, R., Garrenton, L. S., Bermingham, A., et al. (2021) · Cancer Research

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 14