Akatsuka, Shinya

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

Nagai, H., Okazaki, Y., Chew, S. H., Misawa, N., Yamashita, Y., Akatsuka, S., Ishihara, T., Yamashita, K., Yoshikawa, Y., Yasui, H., et al. (2011) · Proceedings of the National Academy of Sciences

Occupational and environmental lung diseasesGraphene and Nanomaterials Applications

Cited by 535

Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis

Toyokuni, S., Ito, F., Yamashita, K., Okazaki, Y., & Akatsuka, S. (2017) · Free Radical Biology and Medicine

Ferroptosis and cancer prognosisGenomics, phytochemicals, and oxidative stress

Cited by 252

Iron overload signature in chrysotile-induced malignant mesothelioma

Jiang, L., Akatsuka, S., Nagai, H., Chew, S., Ohara, H., Okazaki, Y., Yamashita, Y., Yoshikawa, Y., Yasui, H., Ikuta, K., et al. (2012) · The Journal of Pathology

Occupational and environmental lung diseasesOccupational Health and Global Justice

Cited by 104

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer

Akatsuka, S., Yamashita, Y., Ohara, H., Liu, Y.-T., Izumiya, M., Abe, K., Ochiai, M., Jiang, L., Nagai, H., Okazaki, Y., et al. (2012) · PLoS ONE

Genomic variations and chromosomal abnormalitiesCancer Genomics and Diagnostics

Cited by 102

Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma

Hu, Q., Akatsuka, S., Yamashita, Y., Ohara, H., Nagai, H., Okazaki, Y., Takahashi, T., & Toyokuni, S. (2010) · Laboratory Investigation

Occupational and environmental lung diseasesIntraperitoneal and Appendiceal Malignancies

Cited by 62

Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis

Akatsuka, S., Aung, T. T., Dutta, K. K., Jiang, L., Lee, W.-H., Liu, Y.-T., Onuki, J., Shirase, T., Yamasaki, K., Ochi, H., et al. (2006) · The American Journal of Pathology

Carcinogens and Genotoxicity AssessmentDNA Repair Mechanisms

Cited by 51

Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium

Ito, F., Yanatori, I., Maeda, Y., Nimura, K., Ito, S., Hirayama, T., Nagasawa, H., Kohyama, N., Okazaki, Y., Akatsuka, S., et al. (2020) · Redox Biology

Occupational and environmental lung diseasesFerroptosis and cancer prognosis

Cited by 45

Connective tissue growth factor and β‐catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma

Jiang, L., Yamashita, Y., Chew, S., Akatsuka, S., Ukai, S., Wang, S., Nagai, H., Okazaki, Y., Takahashi, T., & Toyokuni, S. (2014) · The Journal of Pathology

Connective Tissue Growth Factor ResearchOccupational and environmental lung diseases

Cited by 34

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering

Toyokuni, S., Kong, Y., Cheng, Z., Sato, K., Hayashi, S., Ito, F., Jiang, L., Yanatori, I., Okazaki, Y., & Akatsuka, S. (2020) · Cancers

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 33

Dual preventive benefits of iron elimination by desferal in asbestos‐induced mesothelial carcinogenesis

Jiang, L., Chew, S., Nakamura, K., Ohara, Y., Akatsuka, S., & Toyokuni, S. (2016) · Cancer Science

Occupational and environmental lung diseasesHeavy Metal Exposure and Toxicity

Cited by 19

Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice

Funahashi, S., Okazaki, Y., Akatsuka, S., Takahashi, T., Sakumi, K., Nakabeppu, Y., & Toyokuni, S. (2020) · Free Radical Research

Occupational and environmental lung diseasesDNA Repair Mechanisms

Cited by 7