Varma, Manthena

Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)

Varma, M. V., Steyn, S. J., Allerton, C., & El-Kattan, A. F. (2015) · Pharmaceutical Research

Computational Drug Discovery MethodsDrug Transport and Resistance Mechanisms

Cited by 334

Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach

Mathialagan, S., Piotrowski, M. A., Tess, D. A., Feng, B., Litchfield, J., & Varma, M. V. (2017) · Drug Metabolism and Disposition

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 128

Biopharmaceutic classification system: a scientific framework for pharmacokinetic optimization in drug research

Varma, M., Khandavilli, S., Ashokraj, Y., Jain, A., Dhanikula, A., Sood, A., Thomas, N., Pillai, O., Sharma, P., Gandhi, R., et al. (2004) · Current Drug Metabolism

Drug Solubulity and Delivery SystemsComputational Drug Discovery Methods

Cited by 107

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Margolskee, A., Darwich, A. S., Pepin, X., Aarons, L., Galetin, A., Rostami-Hodjegan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., et al. (2017) · European Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsPharmaceutical studies and practices

Cited by 69

Model-based approaches to predict drug–drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond

Barton, H. A., Lai, Y., Goosen, T. C., Jones, H. M., El-Kattan, A. F., Gosset, J. R., Lin, J., & Varma, M. V. (2013) · Expert Opinion on Drug Metabolism & Toxicology

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 68

Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs

Kimoto, E., Bi, Y.-A., Kosa, R. E., Tremaine, L. M., & Varma, M. V. S. (2017) · Journal of Pharmaceutical Sciences

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 66

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

De Bruyn, T., Ufuk, A., Cantrill, C., Kosa, R. E., Bi, Y.-A., Niosi, M., Modi, S., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., et al. (2018) · Drug Metabolism and Disposition

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 53

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Darwich, A. S., Margolskee, A., Pepin, X., Aarons, L., Galetin, A., Rostami-Hodjegan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., et al. (2017) · European Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsComputational Drug Discovery Methods

Cited by 45