Wu, Long-Jun

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

Eyo, U. B., Peng, J., Swiatkowski, P., Mukherjee, A., Bispo, A., & Wu, L.-J. (2014) · Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsEpilepsy research and treatment

Cited by 509

Presynaptic and Postsynaptic Amplifications of Neuropathic Pain in the Anterior Cingulate Cortex

Xu, H., Wu, L.-J., Wang, H., Zhang, X., Vadakkan, K. I., Kim, S. S., Steenland, H. W., & Zhuo, M. (2008) · The Journal of Neuroscience

Pain Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

Cited by 370

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

Peng, J., Gu, N., Zhou, L., B Eyo, U., Murugan, M., Gan, W.-B., & Wu, L.-J. (2016) · Nature Communications

Pain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 300

Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome

Zhao, M.-G., Toyoda, H., Ko, S. W., Ding, H.-K., Wu, L.-J., & Zhuo, M. (2005) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 296

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

Wu, L.-J., Wu, G., Sharif, M. R. A., Baker, A., Jia, Y., Fahey, F. H., Luo, H. R., Feener, E. P., & Clapham, D. E. (2012) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeuroprotection in Cerebral Ischemia

Cited by 252

Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory

Suzuki, A., Fukushima, H., Mukawa, T., Toyoda, H., Wu, L.-J., Zhao, M.-G., Xu, H., Shang, Y., Endoh, K., Iwamoto, T., et al. (2011) · Journal of Neuroscience

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 250

How microglia sense and regulate neuronal activity

Umpierre, A. D., & Wu, L. (2021) · Glia

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 237

Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system

Yang, S., Qin, C., Hu, Z.-W., Zhou, L.-Q., Yu, H.-H., Chen, M., Bosco, D. B., Wang, W., Wu, L.-J., & Tian, D.-S. (2021) · Neurobiology of Disease

Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancer

Cited by 232

Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Zhou, L.-J., Peng, J., Xu, Y.-N., Zeng, W.-J., Zhang, J., Wei, X., Mai, C.-L., Lin, Z.-J., Liu, Y., Murugan, M., et al. (2019) · Cell Reports

Pain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 228

Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury

Gu, N., Peng, J., Murugan, M., Wang, X., Eyo, U. B., Sun, D., Ren, Y., DiCicco-Bloom, E., Young, W., Dong, H., et al. (2016) · Cell Reports

Pain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 212

Enhanced Presynaptic Neurotransmitter Release in the Anterior Cingulate Cortex of Mice with Chronic Pain

Zhao, M.-G., Ko, S. W., Wu, L.-J., Toyoda, H., Xu, H., Quan, J., Li, J., Jia, Y., Ren, M., Xu, Z. C., et al. (2006) · The Journal of Neuroscience

Pain Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

Cited by 197

FMRP Acts as a Key Messenger for Dopamine Modulation in the Forebrain

Wang, H., Wu, L.-J., Kim, S. S., Lee, F. J. S., Gong, B., Toyoda, H., Ren, M., Shang, Y.-Z., Xu, H., Liu, F., et al. (2008) · Neuron

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 186

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

Liu, Y., Cheng, A., Li, Y.-J., Yang, Y., Kishimoto, Y., Zhang, S., Wang, Y., Wan, R., Raefsky, S. M., Lu, D., et al. (2019) · Nature Communications

Dietary Effects on HealthSirtuins and Resveratrol in Medicine

Cited by 176

Identification of an Adenylyl Cyclase Inhibitor for Treating Neuropathic and Inflammatory Pain

Wang, H., Xu, H., Wu, L.-J., Kim, S. S., Chen, T., Koga, K., Descalzi, G., Gong, B., Vadakkan, K. I., Zhang, X., et al. (2011) · Science Translational Medicine

Pain Mechanisms and TreatmentsPain Management and Treatment

Cited by 165

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

Xie, M., Liu, Y. U., Zhao, S., Zhang, L., Bosco, D. B., Pang, Y.-P., Zhong, J., Sheth, U., Martens, Y. A., Zhao, N., et al. (2022) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAmyotrophic Lateral Sclerosis Research

Cited by 157

Modulation of Microglial Process Convergence Toward Neuronal Dendrites by Extracellular Calcium

Eyo, U. B., Gu, N., De, S., Dong, H., Richardson, J. R., & Wu, L.-J. (2015) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 154

Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease

Liu, C.-C., Wang, N., Chen, Y., Inoue, Y., Shue, F., Ren, Y., Wang, M., Qiao, W., Ikezu, T. C., Li, Z., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 146

Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

Neal, M. L., Fleming, S. M., Budge, K. M., Boyle, A. M., Kim, C., Alam, G., Beier, E. E., Wu, L., & Richardson, J. R. (2020) · The FASEB Journal

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 123

Selective Activation of Microglia in Spinal Cord but Not Higher Cortical Regions Following Nerve Injury in Adult Mouse

Zhang, F., Vadakkan, K. I., Kim, S. S., Wu, L.-J., Shang, Y., & Zhuo, M. (2008) · Molecular Pain

Pain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 122

NFAT1 Orchestrates Spinal Microglial Transcription and Promotes Microglial Proliferation via c‐MYC Contributing to Nerve Injury‐Induced Neuropathic Pain

Jiang, B., Ding, T., Guo, C., Bai, X., Cao, D., Wu, X., Sha, W., Jiang, M., Wu, L., & Gao, Y. (2022) · Advanced Science

Pain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 54

Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder

Ma, X., Qin, C., Chen, M., Yu, H.-H., Chu, Y.-H., Chen, T.-J., Bosco, D. B., Wu, L.-J., Bu, B.-T., Wang, W., et al. (2021) · Journal of Neuroinflammation

Multiple Sclerosis Research StudiesT-cell and B-cell Immunology

Cited by 52

APOE2 Exacerbates TDP‐43 Related Toxicity in the Absence of Alzheimer Pathology

Meneses, A. D., Koga, S., Li, Z., O'Leary, J., Li, F., Chen, K., Murakami, A., Qiao, W., Kurti, A., Heckman, M. G., et al. (2023) · Annals of Neurology

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 11