Hong, Cynthia

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

Zelcer, N., Hong, C., Boyadjian, R., & Tontonoz, P. (2009) · Science

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 848

Liver X receptors in lipid metabolism: opportunities for drug discovery

Hong, C., & Tontonoz, P. (2014) · Nature Reviews Drug Discovery

Cholesterol and Lipid MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 587

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Guo, D., Reinitz, F., Youssef, M., Hong, C., Nathanson, D., Akhavan, D., Kuga, D., Amzajerdi, A. N., Soto, H., Zhu, S., et al. (2011) · Cancer Discovery

Cancer, Lipids, and MetabolismGlioma Diagnosis and Treatment

Cited by 452

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

Sandhu, J., Li, S., Fairall, L., Pfisterer, S. G., Gurnett, J. E., Xiao, X., Weston, T. A., Vashi, D., Ferrari, A., Orozco, J. L., et al. (2018) · Cell

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 287

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

Ito, A., Hong, C., Rong, X., Zhu, X., Tarling, E. J., Hedde, P. N., Gratton, E., Parks, J., & Tontonoz, P. (2015) · eLife

Cholesterol and Lipid MetabolismImmune Response and Inflammation

Cited by 281

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

Hong, C., & Tontonoz, P. (2008) · Current Opinion in Genetics & Development

Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

Cited by 253

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2

Hong, C., Duit, S., Jalonen, P., Out, R., Scheer, L., Sorrentino, V., Boyadjian, R., Rodenburg, K. W., Foley, E., Korhonen, L., et al. (2010) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismUbiquitin and proteasome pathways

Cited by 142

Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease

Beaven, S. W., Wroblewski, K., Wang, J., Hong, C., Bensinger, S., Tsukamoto, H., & Tontonoz, P. (2011) · Gastroenterology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 131

MafB promotes atherosclerosis by inhibiting foam-cell apoptosis

Hamada, M., Nakamura, M., Tran, M. T. N., Moriguchi, T., Hong, C., Ohsumi, T., Dinh, T. T. H., Kusakabe, M., Hattori, M., Katsumata, T., et al. (2014) · Nature Communications

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 111

The LXR–Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice

Hong, C., Marshall, S. M., McDaniel, A. L., Graham, M., Layne, J. D., Cai, L., Scotti, E., Boyadjian, R., Kim, J., Chamberlain, B. T., et al. (2014) · Cell Metabolism

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 87

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

Zhang, L., Fairall, L., Goult, B. T., Calkin, A. C., Hong, C., Millard, C. J., Tontonoz, P., & Schwabe, J. W. R. (2011) · Genes & Development

Ubiquitin and proteasome pathwaysCholesterol and Lipid Metabolism

Cited by 86

IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

Scotti, E., Calamai, M., Goulbourne, C. N., Zhang, L., Hong, C., Lin, R. R., Choi, J., Pilch, P. F., Fong, L. G., Zou, P., et al. (2013) · Molecular and Cellular Biology

Cellular transport and secretionCholesterol and Lipid Metabolism

Cited by 81

Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists

Scotti, E., Hong, C., Yoshinaga, Y., Tu, Y., Hu, Y., Zelcer, N., Boyadjian, R., de Jong, P. J., Young, S. G., Fong, L. G., et al. (2011) · Molecular and Cellular Biology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 77

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

Calkin, A. C., Goult, B. T., Zhang, L., Fairall, L., Hong, C., Schwabe, J. W. R., & Tontonoz, P. (2011) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysCholesterol and Lipid Metabolism

Cited by 62

The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis

Choi, J., Gao, J., Kim, J., Hong, C., Kim, J., & Tontonoz, P. (2015) · Science Translational Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 49

The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis

Sallam, T., Ito, A., Rong, X., Kim, J., van Stijn, C., Chamberlain, B. T., Jung, M. E., Chao, L. C., Jones, M., Gilliland, T., et al. (2014) · Journal of Lipid Research

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 30

IDOL regulates systemic energy balance through control of neuronal VLDLR expression

Lee, S. D., Priest, C., Bjursell, M., Gao, J., Arneson, D. V., Ahn, I. S., Diamante, G., van Veen, J. E., Massa, M. G., Calkin, A. C., et al. (2019) · Nature Metabolism

Regulation of Appetite and ObesityCholesterol and Lipid Metabolism

Cited by 26