Manfredi, Paolo L.

REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial

Fava, M., Stahl, S., Pani, L., De Martin, S., Pappagallo, M., Guidetti, C., Alimonti, A., Bettini, E., Mangano, R. M., Wessel, T., et al. (2022) · American Journal of Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 83

Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors

Bettini, E., Stahl, S. M., De Martin, S., Mattarei, A., Sgrignani, J., Carignani, C., Nola, S., Locatelli, P., Pappagallo, M., Inturrisi, C. E., et al. (2022) · Pharmaceuticals

Neuroscience and Neuropharmacology ResearchTreatment of Major Depression

Cited by 31

REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study

De Martin, S., Gabbia, D., Folli, F., Bifari, F., Fiorina, P., Ferri, N., Stahl, S., Inturrisi, C. E., Pappagallo, M., Traversa, S., et al. (2021) · Frontiers in Pharmacology

Treatment of Major DepressionNerve injury and regeneration

Cited by 28

The N-methyl-D-aspartate receptor antagonist d-methadone acutely improves depressive-like behavior in the forced swim test performance of rats.

Hanania, T., Manfredi, P., Inturrisi, C., & Vitolo, O. V. (2020) · Experimental and Clinical Psychopharmacology

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 27

Subanalysis of Subjective Cognitive Measures From a Phase 2, Double-Blind, Randomized Trial of REL-1017 in Patients With Major Depressive Disorder

Guidetti, C., Serra, G., Pani, L., Pappagallo, M., Maglio, G., Martin, S. D., Mattarei, A., Folli, F., Manfredi, P. L., & Fava, M. (2023) · The Primary Care Companion For CNS Disorders

Treatment of Major DepressionSchizophrenia research and treatment

Cited by 4

A Phase 2a Double-Blind Randomized Trial of REL-1017 (Esmethadone) in Patients with MDD: Analysis of Subscales from the Symptoms of Depression Questionnaire

Guidetti, C., Fava, M., Pani, L., Pappagallo, M., Serra, G., DeMartin, S., Mattarei, A., & Manfredi, P. L. (2022) · CNS Spectrums

Treatment of Major DepressionBipolar Disorder and Treatment

Cited by 3