Larue, Ross C.

BET proteins promote efficient murine leukemia virus integration at transcription start sites

Sharma, A., Larue, R. C., Plumb, M. R., Malani, N., Male, F., Slaughter, A., Kessl, J. J., Shkriabai, N., Coward, E., Aiyer, S. S., et al. (2013) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchProtein Degradation and Inhibitors

Cited by 193

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis

Kessl, J. J., Kutluay, S. B., Townsend, D., Rebensburg, S., Slaughter, A., Larue, R. C., Shkriabai, N., Bakouche, N., Fuchs, J. R., Bieniasz, P. D., et al. (2016) · Cell

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 152

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

Crowe, B. L., Larue, R. C., Yuan, C., Hess, S., Kvaratskhelia, M., & Foster, M. P. (2016) · Proceedings of the National Academy of Sciences

Protein Degradation and InhibitorsGenomics and Chromatin Dynamics

Cited by 83

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

Aiyer, S., Swapna, G. V. T., Malani, N., Aramini, J. M., Schneider, W. M., Plumb, M. R., Ghanem, M., Larue, R. C., Sharma, A., Studamire, B., et al. (2014) · Nucleic Acids Research

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 72

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

Koneru, P. C., Francis, A. C., Deng, N., Rebensburg, S. V., Hoyte, A. C., Lindenberger, J., Adu-Ampratwum, D., Larue, R. C., Wempe, M. F., Engelman, A. N., et al. (2019) · eLife

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 49

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes

Larue, R. C., Plumb, M. R., Crowe, B. L., Shkriabai, N., Sharma, A., DiFiore, J., Malani, N., Aiyer, S. S., Roth, M. J., Bushman, F. D., et al. (2014) · Nucleic Acids Research

Virus-based gene therapy researchProtein Degradation and Inhibitors

Cited by 44

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

Feng, L., Dharmarajan, V., Serrao, E., Hoyte, A., Larue, R. C., Slaughter, A., Sharma, A., Plumb, M. R., Kessl, J. J., Fuchs, J. R., et al. (2016) · ACS Chemical Biology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 37

A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

Shkriabai, N., Dharmarajan, V., Slaughter, A., Kessl, J. J., Larue, R. C., Feng, L., Fuchs, J. R., Griffin, P. R., & Kvaratskhelia, M. (2014) · Journal of Biological Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 30

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing

Hoyte, A. C., Jamin, A. V., Koneru, P. C., Kobe, M. J., Larue, R. C., Fuchs, J. R., Engelman, A. N., & Kvaratskhelia, M. (2017) · Journal of Biological Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 30

The FACT Complex Promotes Avian Leukosis Virus DNA Integration

Winans, S., Larue, R. C., Abraham, C. M., Shkriabai, N., Skopp, A., Winkler, D., Kvaratskhelia, M., & Beemon, K. L. (2017) · Journal of Virology

Virus-based gene therapy researchHIV Research and Treatment

Cited by 26