Cox, Adrienne D.

Drugging the undruggable RAS: Mission Possible?

Cox, A. D., Fesik, S. W., Kimmelman, A. C., Luo, J., & Der, C. J. (2014) · Nature Reviews Drug Discovery

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 1,997

Ras history: The saga continues

Cox, A. D., & Der, C. J. (2010) · Small GTPases

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 706

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., et al. (2019) · Nature Medicine

Autophagy in Disease and TherapyPancreatic and Hepatic Oncology Research

Cited by 692

Ras signalling on the endoplasmic reticulum and the Golgi

Chiu, V. K., Bivona, T., Hach, A., Sajous, J. B., Silletti, J., Wiener, H., Johnson, R. L., Cox, A. D., & Philips, M. R. (2002) · Nature Cell Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 594

RALA and RALBP1 regulate mitochondrial fission at mitosis

Kashatus, D. F., Lim, K.-H., Brady, D. C., Pershing, N. L. K., Cox, A. D., & Counter, C. M. (2011) · Nature Cell Biology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 380

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification

Roberts, P. J., Mitin, N., Keller, P. J., Chenette, E. J., Madigan, J. P., Currin, R. O., Cox, A. D., Wilson, O., Kirschmeier, P., & Der, C. J. (2008) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 362

Activation of RalA is critical for Ras-induced tumorigenesis of human cells

Lim, K.-H., Baines, A. T., Fiordalisi, J. J., Shipitsin, M., Feig, L. A., Cox, A. D., Der, C. J., & Counter, C. M. (2005) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 355

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

Cox, A. D., Der, C. J., & Philips, M. R. (2015) · Clinical Cancer Research

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 351

Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

Hobbs, G. A., Baker, N. M., Miermont, A. M., Thurman, R. D., Pierobon, M., Tran, T. H., Anderson, A. O., Waters, A. M., Diehl, J. N., Papke, B., et al. (2020) · Cancer Discovery

Protein Kinase Regulation and GTPase SignalingPancreatic and Hepatic Oncology Research

Cited by 231

Combination Therapies with CDK4/6 Inhibitors to Treat KRAS- Mutant Pancreatic Cancer

Goodwin, C. M., Waters, A. M., Klomp, J. E., Javaid, S., Bryant, K. L., Stalnecker, C. A., Drizyte-Miller, K., Papke, B., Yang, R., Amparo, A. M., et al. (2023) · Cancer Research

Pancreatic and Hepatic Oncology ResearchAdvanced Breast Cancer Therapies

Cited by 168

The role of wild type RAS isoforms in cancer

Zhou, B., Der, C. J., & Cox, A. D. (2016) · Seminars in Cell & Developmental Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 130

Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA

Lim, K.-H., Brady, D. C., Kashatus, D. F., Ancrile, B. B., Der, C. J., Cox, A. D., & Counter, C. M. (2010) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingMicrotubule and mitosis dynamics

Cited by 126

TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors

Edwards, A. C., Stalnecker, C. A., Jean Morales, A., Taylor, K. E., Klomp, J. E., Klomp, J. A., Waters, A. M., Sudhakar, N., Hallin, J., Tang, T. T., et al. (2023) · Cancer Research

Hippo pathway signaling and YAP/TAZProtein Kinase Regulation and GTPase Signaling

Cited by 91

Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

Klomp, J. E., Diehl, J. N., Klomp, J. A., Edwards, A. C., Yang, R., Morales, A. J., Taylor, K. E., Drizyte-Miller, K., Bryant, K. L., Schaefer, A., et al. (2024) · Science

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 83

Phosphorylation by Protein Kinase Cα Regulates RalB Small GTPase Protein Activation, Subcellular Localization, and Effector Utilization

Martin, T. D., Mitin, N., Cox, A. D., Yeh, J. J., & Der, C. J. (2012) · Journal of Biological Chemistry

Cellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Cited by 38

Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation

Kidd, A. R., Snider, J. L., Martin, T. D., Graboski, S. F., Der, C. J., & Cox, A. D. (2010) · International Journal of Radiation Oncology*Biology*Physics

Protein Kinase Regulation and GTPase SignalingEffects of Radiation Exposure

Cited by 25

Silencing of Oncogenic KRAS by Mutant-Selective Small Interfering RNA

Papke, B., Azam, S. H., Feng, A. Y., Gutierrez-Ford, C., Huggins, H., Pallan, P. S., Van Swearingen, A. E. D., Egli, M., Cox, A. D., Der, C. J., et al. (2021) · ACS Pharmacology & Translational Science

RNA Interference and Gene DeliveryProtein Kinase Regulation and GTPase Signaling

Cited by 22

Abstract 1936: KEAP1-NRF2 mediated resistance against KRASG12D inhibitor in pancreatic ductal adenocarcinoma

Chang, W.-H., Stamey, A. G., Waters, A. M., Bryant, K. L., Cox, A. D., & Der, C. J. (2024) · Cancer Research

Pancreatic and Hepatic Oncology ResearchGenomics, phytochemicals, and oxidative stress

Cited by 1