Fritsche, Lars G.

A global reference for human genetic variation

The 1000 Genomes Project Consortium, authors, C., Auton, A., Abecasis, G. R., Steering committee, Altshuler, D. M., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., et al. (2015) · Nature

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 18,247

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

23andMe Research Team, Liu, M., Psychiatry, H. A.-I., Jiang, Y., Wedow, R., Li, Y., Brazel, D. M., Chen, F., Datta, G., Davila-Velderrain, J., et al. (2019) · Nature Genetics

Genetic Associations and EpidemiologySmoking Behavior and Cessation

Cited by 1,896

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., et al. (2016) · Nature Genetics

Retinal Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 1,544

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Wightman, D. P., Jansen, I. E., Savage, J. E., Shadrin, A. A., Bahrami, S., Holland, D., Rongve, A., Børte, S., Winsvold, B. S., Drange, O. K., et al. (2021) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,011

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

Nielsen, J. B., Thorolfsdottir, R. B., Fritsche, L. G., Zhou, W., Skov, M. W., Graham, S. E., Herron, T. J., McCarthy, S., Schmidt, E. M., Sveinbjornsson, G., et al. (2018) · Nature Genetics

Cardiac electrophysiology and arrhythmiasAtrial Fibrillation Management and Outcomes

Cited by 876

Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk

Rivera, A., Fisher, S. A., Fritsche, L. G., Keilhauer, C. N., Lichtner, P., Meitinger, T., & Weber, B. H. F. (2005) · Human Molecular Genetics

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 788

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

23andMe Research Team, Ferreira, M. A., collaborators, A., BIOS consortium, Study, L. C., Vonk, J. M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J. D., et al. (2017) · Nature Genetics

Asthma and respiratory diseasesGenetic Associations and Epidemiology

Cited by 550

Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA

Fritsche, L. G., Loenhardt, T., Janssen, A., Fisher, S. A., Rivera, A., Keilhauer, C. N., & Weber, B. H. F. (2008) · Nature Genetics

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 400

Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

Ratnapriya, R., Sosina, O. A., Starostik, M. R., Kwicklis, M., Kapphahn, R. J., Fritsche, L. G., Walton, A., Arvanitis, M., Gieser, L., Pietraszkiewicz, A., et al. (2019) · Nature Genetics

Retinal Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 312

CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors

Corbo, J. C., Lawrence, K. A., Karlstetter, M., Myers, C. A., Abdelaziz, M., Dirkes, W., Weigelt, K., Seifert, M., Benes, V., Fritsche, L. G., et al. (2010) · Genome Research

Retinal Development and DisordersGenomics and Chromatin Dynamics

Cited by 219

An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

Fritsche, L. G., Lauer, N., Hartmann, A., Stippa, S., Keilhauer, C. N., Oppermann, M., Pandey, M. K., Köhl, J., Zipfel, P. F., Weber, B. H. F., et al. (2010) · Human Molecular Genetics

Complement system in diseasesRetinal Diseases and Treatments

Cited by 203

Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration

Skerka, C., Lauer, N., Weinberger, A. A. W. A., Keilhauer, C. N., Sühnel, J., Smith, R., Schlötzer–Schrehardt, U., Fritsche, L., Heinen, S., & Hartmann, A. (2007) · Molecular Immunology

Complement system in diseasesRetinal Diseases and Treatments

Cited by 197

Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies

McKay, G. J., Patterson, C. C., Chakravarthy, U., Dasari, S., Klaver, C. C., Vingerling, J. R., Ho, L., de Jong, P. T. V. M., Fletcher, A. E., Young, I. S., et al. (2011) · Human Mutation

Retinal Diseases and TreatmentsRetinal Imaging and Analysis

Cited by 151

GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

Zhou, W., Brumpton, B., Kabil, O., Gudmundsson, J., Thorleifsson, G., Weinstock, J., Zawistowski, M., Nielsen, J. B., Chaker, L., Medici, M., et al. (2020) · Nature Communications

Genetic Associations and EpidemiologyThyroid Disorders and Treatments

Cited by 129

Genome-wide analysis yields new loci associating with aortic valve stenosis

Helgadottir, A., Thorleifsson, G., Gretarsdottir, S., Stefansson, O. A., Tragante, V., Thorolfsdottir, R. B., Jonsdottir, I., Bjornsson, T., Steinthorsdottir, V., Verweij, N., et al. (2018) · Nature Communications

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 125

The HUNT Study: a population-based cohort for genetic research

Brumpton, B. M., Graham, S., Surakka, I., Skogholt, A. H., Løset, M., Fritsche, L. G., Wolford, B., Zhou, W., Nielsen, J. B., Holmen, O. L., et al. (2021) · Cell Genomics

Genetic Associations and EpidemiologyHealth, Environment, Cognitive Aging

Cited by 110

Variations in Apolipoprotein E Frequency With Age in a Pooled Analysis of a Large Group of Older People

McKay, G. J., Silvestri, G., Chakravarthy, U., Dasari, S., Fritsche, L. G., Weber, B. H., Keilhauer, C. N., Klein, M. L., Francis, P. J., Klaver, C. C., et al. (2011) · American Journal of Epidemiology

Lipoproteins and Cardiovascular HealthRetinal Diseases and Treatments

Cited by 105

No Clinically Significant Association between CFH and ARMS2 Genotypes and Response to Nutritional Supplements

Chew, E. Y., Klein, M. L., Clemons, T. E., Agrón, E., Ratnapriya, R., Edwards, A. O., Fritsche, L. G., Swaroop, A., & Abecasis, G. R. (2014) · Ophthalmology

Retinal Diseases and TreatmentsNutrition, Genetics, and Disease

Cited by 94

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

Strunz, T., Lauwen, S., Kiel, C., International AMD Genomics Consortium (IAMDGC), Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., et al. (2020) · Scientific Reports

Genetic Associations and EpidemiologyRetinal Diseases and Treatments

Cited by 60

Correction: Systemic Complement Activation in Age-Related Macular Degeneration

Scholl, H. P. N., Charbel Issa, P., Walier, M., Janzer, S., Pollok-Kopp, B., Börncke, F., Fritsche, L. G., Chong, N. V., Fimmers, R., Wienker, T., et al. (2008) · PLoS ONE

Complement system in diseasesRetinal Diseases and Treatments

Cited by 39