Fischer, Eric S.

Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

Shirasaki, R., Matthews, G. M., Gandolfi, S., de Matos Simoes, R., Buckley, D. L., Raja Vora, J., Sievers, Q. L., Brüggenthies, J. B., Dashevsky, O., Poarch, H., et al. (2021) · Cell Reports

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 123

Design principles for cyclin K molecular glue degraders

Kozicka, Z., Suchyta, D. J., Focht, V., Kempf, G., Petzold, G., Jentzsch, M., Zou, C., Di Genua, C., Donovan, K. A., Coomar, S., et al. (2024) · Nature Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 113

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

Tsai, J. M., Aguirre, J. D., Li, Y.-D., Brown, J., Focht, V., Kater, L., Kempf, G., Sandoval, B., Schmitt, S., Rutter, J. C., et al. (2023) · Molecular Cell

Estrogen and related hormone effectsUbiquitin and proteasome pathways

Cited by 68

Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216

Teng, M., Lu, W., Donovan, K. A., Sun, J., Krupnick, N. M., Nowak, R. P., Li, Y.-D., Sperling, A. S., Zhang, T., Ebert, B. L., et al. (2022) · Journal of Medicinal Chemistry

Protein Degradation and InhibitorsChemical Synthesis and Analysis

Cited by 63

Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library

Razumkov, H., Jiang, Z., Baek, K., You, I., Geng, Q., Donovan, K. A., Tang, M. T., Metivier, R. J., Mageed, N., Seo, P., et al. (2024) · Journal of the American Chemical Society

Protein Degradation and InhibitorsChemical Synthesis and Analysis

Cited by 53

Machine Learning Modeling of Protein-Intrinsic Features Predicts Tractability of Targeted Protein Degradation

Zhang, W., Roy Burman, S. S., Chen, J., Donovan, K. A., Cao, Y., Shu, C., Zhang, B., Zeng, Z., Gu, S., Zhang, Y., et al. (2022) · Genomics, Proteomics & Bioinformatics

Protein Degradation and InhibitorsComputational Drug Discovery Methods

Cited by 51

Machine learning modeling of protein-intrinsic features predicts tractability of targeted protein degradation

Zhang, W., Roy Burman, S. S., Chen, J., Donovan, K. A., Cao, Y., Zhang, B., Zeng, Z., Zhang, Y., Li, D., Fischer, E. S., et al. (2021) · Genomics Proteomics & Bioinformatics

Protein Degradation and InhibitorsComputational Drug Discovery Methods

Cited by 51

Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases

Hunkeler, M., Jin, C. Y., & Fischer, E. S. (2023) · Science

Cell death mechanisms and regulationUbiquitin and proteasome pathways

Cited by 48

Targeting oncoproteins with a positive selection assay for protein degraders

Koduri, V., Duplaquet, L., Lampson, B. L., Wang, A. C., Sabet, A. H., Ishoey, M., Paulk, J., Teng, M., Harris, I. S., Endress, J. E., et al. (2021) · Science Advances

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 44

Targeted Degradation of the Oncogenic Phosphatase SHP2

Vemulapalli, V., Donovan, K. A., Seegar, T. C. M., Rogers, J. M., Bae, M., Lumpkin, R. J., Cao, R., Henke, M. T., Ray, S. S., Fischer, E. S., et al. (2021) · Biochemistry

Protein Tyrosine PhosphatasesProtein Degradation and Inhibitors

Cited by 43

Polymerization of ZBTB transcription factors regulates chromatin occupancy

Park, P. M. C., Park, J., Brown, J., Hunkeler, M., Roy Burman, S. S., Donovan, K. A., Yoon, H., Nowak, R. P., Słabicki, M., Ebert, B. L., et al. (2024) · Molecular Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 22

Structural ubiquitin contributes to K48 linkage-specificity of the HECT ligase Tom1

Warner, K., Hunkeler, M., Baek, K., Schmoker, A., Roy Burman, S. S., Overwijn, D., Jin, C., Donovan, K. A., & Fischer, E. S. (2024) · Cell Reports

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 8

Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues

Ojeda, S., Wang, M., Baek, K., Bourgeois, W., Sommerschield, A., Yue, H., Metivier, R. J., Karagiannis, P., Levitz, T. S., Xiong, Y., et al. (2026) · Science

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 5