Hum, Dean W.

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

Ratziu, V., Harrison, S. A., Francque, S., Bedossa, P., Lehert, P., Serfaty, L., Romero-Gomez, M., Boursier, J., Abdelmalek, M., Caldwell, S., et al. (2016) · Gastroenterology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 1,035

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: Hepatology

Staels, B., Rubenstrunk, A., Noel, B., Rigou, G., Delataille, P., Millatt, L. J., Baron, M., Lucas, A., Tailleux, A., Hum, D. W., et al. (2013) · Hepatology

Liver Disease Diagnosis and TreatmentPeroxisome Proliferator-Activated Receptors

Cited by 414

Relative Enzymatic Activity, Protein Stability, and Tissue Distribution of Human Steroid-Metabolizing UGT2B Subfamily Members**This work was supported by the Medical Research Council of Canada, the Fonds de la Recherche en Sante du Quebec, and Endorecherche.

Turgeon, D., Carrier, J.-S., Lévesque, E., Hum, D. W., & Bélanger, A. (2001) · Endocrinology

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 333

Safety issues and prospects for future generations of PPAR modulators

RUBENSTRUNK, A., HANF, R., HUM, D., FRUCHART, J., & STAELS, B. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Peroxisome Proliferator-Activated ReceptorsParaoxonase enzyme and polymorphisms

Cited by 309

Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300

Monté, D., DeWitte, F., & Hum, D. W. (1998) · Journal of Biological Chemistry

Adrenal Hormones and DisordersEstrogen and related hormone effects

Cited by 147

Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues

Bélanger, A., Hum, D. W., Beaulieu, M., Lévesque, É., Guillemette, C., Tchernof, A., Bélanger, G., Turgeon, D., & Dubois, S. (1998) · The Journal of Steroid Biochemistry and Molecular Biology

Pharmacogenetics and Drug MetabolismProstate Cancer Treatment and Research

Cited by 131

Identification of positive and negative placenta-specific basal elements and a cyclic adenosine 3',5'-monophosphate response element in the human gene for P450scc.

Moore, C. C., Hum, D. W., & Miller, W. L. (1992) · Molecular Endocrinology

Estrogen and related hormone effectsGenomics and Chromatin Dynamics

Cited by 68

Gene conversion in the CYP11B2 gene encoding P450c11AS is associated with, but does not cause, the syndrome of corticosterone methyloxidase II deficiency.

Fardella, C. E., Hum, D. W., Rodriguez, H., Zhang, G., Barry, F. L., Ilicki, A., Bloch, C. A., & Miller, W. L. (1996) · The Journal of Clinical Endocrinology & Metabolism

Hormonal Regulation and HypertensionAdrenal Hormones and Disorders

Cited by 60

The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells

Gizard, F., Lavallée, B., DeWitte, F., Teissier, E., Staels, B., & Hum, D. W. (2002) · Journal of Biological Chemistry

Adrenal Hormones and DisordersEstrogen and related hormone effects

Cited by 58

A Novel Zinc Finger Protein TReP-132 Interacts with CBP/p300 to Regulate Human CYP11A1 Gene Expression

Gizard, F., Lavallée, B., DeWitte, F., & Hum, D. W. (2001) · Journal of Biological Chemistry

Estrogen and related hormone effectsGenomics and Chromatin Dynamics

Cited by 52

Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method

Tchernof, A., Lévesque, É., Beaulieu, M., Couture, P., Després, J., Hum, D. W., & Bélanger, A. (1999) · Clinical Endocrinology

Hormonal and reproductive studiesPharmacogenetics and Drug Metabolism

Cited by 50

Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: a model for low-renin hypertension?

Fardella, C. E., Rodriguez, H., Hum, D. W., Mellon, S. H., & Miller, W. L. (1995) · The Journal of Clinical Endocrinology & Metabolism

Hormonal Regulation and HypertensionRenin-Angiotensin System Studies

Cited by 31

Baseline Parameters in Clinical Trials for Nonalcoholic Steatohepatitis: Recommendations From the Liver Forum

Patel, Y. A., Imperial, J. C., Muir, A. J., Anstee, Q. M., DeBrota, D., Dimick-Santos, L., Filozof, C., Mehta, R., Sanyal, A. J., Schabel, E., et al. (2017) · Gastroenterology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 25