Flügel, Alexander

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions.

Bartholomäus, I., Kawakami, N., Odoardi, F., Schläger, C., Miljkovic, D., Ellwart, J. W., Klinkert, W. E. F., Flügel-Koch, C., Issekutz, T. B., Wekerle, H., et al. (2009) · Nature

Multiple Sclerosis Research StudiesT-cell and B-cell Immunology

Cited by 685

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment

Priller, J., Flügel, A., Wehner, T., Boentert, M., Haas, C. A., Prinz, M., Fernández-Klett, F., Prass, K., Bechmann, I., de Boer, B. A., et al. (2001) · Nature Medicine

Virus-based gene therapy researchBarrier Structure and Function Studies

Cited by 637

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

Schläger, C., Körner, H., Krueger, M., Vidoli, S., Haberl, M., Mielke, D., Brylla, E., Issekutz, T., Cabañas, C., Nelson, P. J., et al. (2016) · Nature

Multiple Sclerosis Research StudiesT-cell and B-cell Immunology

Cited by 372

Vascular, glial, and lymphatic immune gateways of the central nervous system

Engelhardt, B., Carare, R. O., Bechmann, I., Flügel, A., Laman, J. D., & Weller, R. O. (2016) · Acta Neuropathologica

Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus

Cited by 362

A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity

Lodygin, D., Odoardi, F., Schläger, C., Körner, H., Kitz, A., Nosov, M., van den Brandt, J., Reichardt, H. M., Haberl, M., & Flügel, A. (2013) · Nature Medicine

Multiple Sclerosis Research StudiesT-cell and B-cell Immunology

Cited by 144

β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration

Lodygin, D., Hermann, M., Schweingruber, N., Flügel-Koch, C., Watanabe, T., Schlosser, C., Merlini, A., Körner, H., Chang, H.-F., Fischer, H. J., et al. (2019) · Nature

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 140

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Schäffner, E., Bosch-Queralt, M., Edgar, J. M., Lehning, M., Strauß, J., Fleischer, N., Kungl, T., Wieghofer, P., Berghoff, S. A., Reinert, T., et al. (2023) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 101

Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

Li, Z., Korhonen, E. A., Merlini, A., Strauss, J., Wihuri, E., Nurmi, H., Antila, S., Paech, J., Deutsch, U., Engelhardt, B., et al. (2020) · Journal of Clinical Investigation

Multiple Sclerosis Research StudiesBarrier Structure and Function Studies

Cited by 52

A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats

Müller, N., van den Brandt, J., Odoardi, F., Tischner, D., Herath, J., Flügel, A., & Reichardt, H. M. (2008) · Journal of Clinical Investigation

T-cell and B-cell ImmunologyImmunotoxicology and immune responses

Cited by 46