Muthusamy, Natarajan

Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes

Dubovsky, J. A., Beckwith, K. A., Natarajan, G., Woyach, J. A., Jaglowski, S., Zhong, Y., Hessler, J. D., Liu, T.-M., Chang, B. Y., Larkin, K. M., et al. (2013) · Blood

Chronic Lymphocytic Leukemia ResearchT-cell and B-cell Immunology

Cited by 810

Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

Fraietta, J. A., Beckwith, K. A., Patel, P. R., Ruella, M., Zheng, Z., Barrett, D. M., Lacey, S. F., Melenhorst, J. J., McGettigan, S. E., Cook, D. R., et al. (2016) · Blood

CAR-T cell therapy researchChronic Lymphocytic Leukemia Research

Cited by 474

Defective activation and survival of T cells lacking the Ets-1 transcription factor

Muthusamy, N., Barton, K., & Leiden, J. M. (1995) · Nature

T-cell and B-cell ImmunologyGenomics and Chromatin Dynamics

Cited by 330

Nitric Oxide Production by Myeloid Derived Suppressor Cells Plays a Role in Impairing Fc Receptor-Mediated Natural Killer Cell Function.

Stiff, A., Trikha, P., Mundy-Bosse, B., McMichael, E., Mace, T. A., Benner, B., Kendra, K., Campbell, A., Gautam, S., Abood, D., et al. (2018) · Clinical Cancer Research

Immune cells in cancerImmune Cell Function and Interaction

Cited by 244

Myeloid-derived suppressor cells express Bruton's tyrosine kinase and can be depleted in tumor-bearing hosts by ibrutinib treatment

Stiff, A., Trikha, P., Wesolowski, R., Kendra, K., Hsu, V., Uppati, S., McMichael, E., Duggan, M., Campbell, A., Keller, K., et al. (2016) · Cancer Research

Immune cells in cancerImmunotherapy and Immune Responses

Cited by 188

Ets1 and ets2 are required for endothelial cell survival during embryonic angiogenesis

Wei, G., Srinivasan, R., Cantemir-Stone, C. Z., Sharma, S. M., Santhanam, R., Weinstein, M., Muthusamy, N., Man, A. K., Oshima, R. G., Leone, G., et al. (2009) · Blood

Angiogenesis and VEGF in CancerDevelopmental Biology and Gene Regulation

Cited by 185

Defective B cell receptor‐mediated responses in mice lacking the Ets protein, Spi‐B

Su, G. H., Chen, H., Muthusamy, N., Garrett‐Sinha, L. A., Baunoch, D., Tenen, D. G., & Simon, M. C. (1997) · The EMBO Journal

T-cell and B-cell ImmunologyGenomics and Chromatin Dynamics

Cited by 182

Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts

Vasu, S., He, S., Cheney, C., Gopalakrishnan, B., Mani, R., Lozanski, G., Mo, X., Groh, V., Whitman, S. P., Konopitzky, R., et al. (2016) · Blood

Acute Myeloid Leukemia ResearchImmune Cell Function and Interaction

Cited by 93

PI3K p110δ inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression

Dong, S., Harrington, B. K., Hu, E. Y., Greene, J. T., Lehman, A. M., Tran, M., Wasmuth, R. L., Long, M., Muthusamy, N., Brown, J. R., et al. (2018) · Journal of Clinical Investigation

Chronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and Treatment

Cited by 52

Activation of Lyn, Blk, and Btk But Not Syk in CD72-Stimulated B Lymphocytes

Venkataraman, C., Muthusamy, N., Muthukkumar, S., & Bondada, S. (1998) · The Journal of Immunology

T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disorders

Cited by 52