Lien, Evan C.

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

Lien, E. C., Lyssiotis, C. A., Juvekar, A., Hu, H., Asara, J. M., Cantley, L. C., & Toker, A. (2016) · Nature Cell Biology

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 249

Altered exocrine function can drive adipose wasting in early pancreatic cancer

Danai, L. V., Babic, A., Rosenthal, M. H., Dennstedt, E. A., Muir, A., Lien, E. C., Mayers, J. R., Tai, K., Lau, A. N., Jones-Sali, P., et al. (2018) · Nature

Pancreatic and Hepatic Oncology ResearchNutrition and Health in Aging

Cited by 141

A framework for examining how diet impacts tumour metabolism

Lien, E. C., & Vander Heiden, M. G. (2019) · Nature reviews. Cancer

Cancer, Hypoxia, and MetabolismDietary Effects on Health

Cited by 139

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

Juvekar, A., Hu, H., Yadegarynia, S., Lyssiotis, C. A., Ullas, S., Lien, E. C., Bellinger, G., Son, J., Hok, R. C., Seth, P., et al. (2016) · Proceedings of the National Academy of Sciences

PARP inhibition in cancer therapyPI3K/AKT/mTOR signaling in cancer

Cited by 93

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

Li, Z., Ji, B. W., Dixit, P. D., Tchourine, K., Lien, E. C., Hosios, A. M., Abbott, K. L., Rutter, J. C., Westermark, A. M., Gorodetsky, E. F., et al. (2022) · Nature Metabolism

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 81