Karoly, Edward D.

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

Sukumar, M., Liu, J., Ji, Y., Subramanian, M., Crompton, J. G., Yu, Z., Roychoudhuri, R., Palmer, D. C., Muranski, P., Karoly, E. D., et al. (2013) · Journal of Clinical Investigation

T-cell and B-cell ImmunologyCancer, Hypoxia, and Metabolism

Cited by 952

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

Reitman, Z. J., Jin, G., Karoly, E. D., Spasojevic, I., Yang, J., Kinzler, K. W., He, Y., Bigner, D. D., Vogelstein, B., & Yan, H. (2011) · Proceedings of the National Academy of Sciences

Glioma Diagnosis and TreatmentCancer, Hypoxia, and Metabolism

Cited by 449

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

Terunuma, A., Putluri, N., Mishra, P., Mathé, E. A., Dorsey, T. H., Yi, M., Wallace, T. A., Issaq, H. J., Zhou, M., Killian, J. K., et al. (2014) · Journal of Clinical Investigation

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 428

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

Lotta, L. A., Scott, R. A., Sharp, S. J., Burgess, S., Luan, J., Tillin, T., Schmidt, A. F., Imamura, F., Stewart, I. D., Perry, J. R. B., et al. (2016) · PLOS Medicine

Genetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 417

Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease

James, E. L., Michalek, R. D., Pitiyage, G. N., de Castro, A. M., Vignola, K. S., Jones, J., Mohney, R. P., Karoly, E. D., Prime, S. S., & Parkinson, E. K. (2015) · Journal of Proteome Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 231

Metabolomic analysis of prostate cancer risk in a prospective cohort: The alpha‐tocopherol, beta‐carotene cancer prevention (ATBC) study

Mondul, A. M., Moore, S. C., Weinstein, S. J., Karoly, E. D., Sampson, J. N., & Albanes, D. (2015) · International Journal of Cancer

Metabolomics and Mass Spectrometry StudiesProstate Cancer Treatment and Research

Cited by 179

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

Labbé, D. P., Zadra, G., Yang, M., Reyes, J. M., Lin, C. Y., Cacciatore, S., Ebot, E. M., Creech, A. L., Giunchi, F., Fiorentino, M., et al. (2019) · Nature Communications

Cancer, Lipids, and MetabolismProstate Cancer Treatment and Research

Cited by 174

Oncogene-induced senescence results in marked metabolic and bioenergetic alterations

Quijano, C., Cao, L., Fergusson, M. M., Romero, H., Liu, J., Gutkind, S., Rovira, I. I., Mohney, R. P., Karoly, E. D., & Finkel, T. (2012) · Cell Cycle

Telomeres, Telomerase, and SenescenceCancer, Lipids, and Metabolism

Cited by 155

Metabolomic Differences in Heart Failure Patients With and Without Major Depression

Steffens, D. C., Jiang, W., Krishnan, K. R. R., Karoly, E. D., Mitchell, M. W., O'Connor, C. M., & Kaddurah-Daouk, R. (2010) · Journal of Geriatric Psychiatry and Neurology

Metabolomics and Mass Spectrometry StudiesTryptophan and brain disorders

Cited by 68