Coghlan, Matthew P.

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

Willard, F. S., Douros, J. D., Gabe, M. B. N., Showalter, A. D., Wainscott, D. B., Suter, T. M., Capozzi, M. E., van der Velden, W. J. C., Stutsman, C., Cardona, G. R., et al. (2020) · JCI Insight

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How May GIP Enhance the Therapeutic Efficacy of GLP-1?

Samms, R. J., Coghlan, M. P., & Sloop, K. W. (2020) · Trends in Endocrinology & Metabolism

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

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GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice

Samms, R. J., Christe, M. E., Collins, K. A. L., Pirro, V., Droz, B. A., Holland, A. K., Friedrich, J. L., Wojnicki, S., Konkol, D. L., Cosgrove, R., et al. (2021) · Journal of Clinical Investigation

Diabetes Treatment and ManagementAdipokines, Inflammation, and Metabolic Diseases

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Robust anti‐obesity and metabolic effects of a dual GLP ‐1/glucagon receptor peptide agonist in rodents and non‐human primates

Henderson, S. J., Konkar, A., Hornigold, D. C., Trevaskis, J. L., Jackson, R., Fritsch Fredin, M., Jansson‐Löfmark, R., Naylor, J., Rossi, A., Bednarek, M. A., et al. (2016) · Diabetes, Obesity and Metabolism

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

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Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

Kawai, T., Sun, B., Yoshino, H., Feng, D., Suzuki, Y., Fukazawa, M., Nagao, S., Wainscott, D. B., Showalter, A. D., Droz, B. A., et al. (2020) · Proceedings of the National Academy of Sciences

Receptor Mechanisms and SignalingDiabetes Treatment and Management

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Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

Lochhead, P. A., Coghlan, M., Rice, S. Q. J., & Sutherland, C. (2001) · Diabetes

Metabolism, Diabetes, and CancerWnt/β-catenin signaling in development and cancer

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c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor

Behre, G., Whitmarsh, A. J., Coghlan, M. P., Hoang, T., Carpenter, C. L., Zhang, D.-E., Davis, R. J., & Tenen, D. G. (1999) · Journal of Biological Chemistry

Genomics and Chromatin DynamicsCytokine Signaling Pathways and Interactions

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Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis

Aiston, S., Coghlan, M. P., & Agius, L. (2003) · European Journal of Biochemistry

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

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Tirzepatide leads to weight reduction in people with obesity due to MC4R deficiency

Bhatnagar, P., Ahmad, N. N., Li, X., Coghlan, M., Kaplan, L. M., & Farooqi, I. S. (2025) · Nature Medicine

Pharmacology and Obesity TreatmentRegulation of Appetite and Obesity

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