Marquez, Abby

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Nichols, R. J., Haderk, F., Stahlhut, C., Schulze, C. J., Hemmati, G., Wildes, D., Tzitzilonis, C., Mordec, K., Marquez, A., Romero, J., et al. (2018) · Nature Cell Biology

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Holderfield, M., Lee, B. J., Jiang, J., Tomlinson, A., Seamon, K. J., Mira, A., Patrucco, E., Goodhart, G., Dilly, J., Gindin, Y., et al. (2024) · Nature

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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Translational and therapeutic evaluation of RAS-GTP inhibition by RMC-6236 in RAS-driven cancers

Jiang, J., Jiang, L., Maldonato, B. J., Wang, Y., Holderfield, M., Aronchik, I., Winters, I. P., Salman, Z., Blaj, C., Menard, M., et al. (2024) · Cancer Discovery

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

Schulze, C. J., Seamon, K. J., Zhao, Y., Yang, Y. C., Cregg, J., Kim, D., Tomlinson, A., Choy, T. J., Wang, Z., Sang, B., et al. (2023) · Science

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors

Burnett, G. L., Yang, Y. C., Aggen, J. B., Pitzen, J., Gliedt, M. K., Semko, C. M., Marquez, A., Evans, J. W., Wang, G., Won, W. S., et al. (2023) · Journal of Medicinal Chemistry

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

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