Schlothauer, Tilman

Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions

Schlothauer, T., Herter, S., Koller, C. F., Grau-Richards, S., Steinhart, V., Spick, C., Kubbies, M., Klein, C., Umaña, P., & Mössner, E. (2016) · Protein Engineering Design and Selection

Monoclonal and Polyclonal Antibodies ResearchProtein purification and stability

Cited by 425

Determination of critical quality attributes for monoclonal antibodies using quality by design principles

Alt, N., Zhang, T. Y., Motchnik, P., Taticek, R., Quarmby, V., Schlothauer, T., Beck, H., Emrich, T., & Harris, R. J. (2016) · Biologicals

Protein purification and stabilityBiosimilars and Bioanalytical Methods

Cited by 294

In vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activity

Thomann, M., Schlothauer, T., Dashivets, T., Malik, S., Avenal, C., Bulau, P., Rüger, P., & Reusch, D. (2015) · PLOS ONE

Monoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins Research

Cited by 220

Multi-angle effector function analysis of human monoclonal IgG glycovariants

Dashivets, T., Thomann, M., Rueger, P., Knaupp, A., Buchner, J., & Schlothauer, T. (2015) · PLOS ONE

Monoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins Research

Cited by 101

A human endothelial cell-based recycling assay for screening of FcRn targeted molecules

Grevys, A., Nilsen, J., Sand, K. M. K., Daba, M. B., Øynebråten, I., Bern, M., McAdam, M. B., Foss, S., Schlothauer, T., Michaelsen, T. E., et al. (2018) · Nature Communications

Monoclonal and Polyclonal Antibodies ResearchDrug Transport and Resistance Mechanisms

Cited by 98

Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life

Grevys, A., Frick, R., Mester, S., Flem-Karlsen, K., Nilsen, J., Foss, S., Sand, K. M. K., Emrich, T., Fischer, J. A. A., Greiff, V., et al. (2022) · iScience

Monoclonal and Polyclonal Antibodies ResearchProtein purification and stability

Cited by 51