Costa, Ana S. H.

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijević, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N. J., Smith, A. C., et al. (2014) · Nature

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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Mills, E. L., Kelly, B., Logan, A., Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., et al. (2016) · Cell

Immune cells in cancerMitochondrial Function and Pathology

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., et al. (2018) · Nature

Genomics, phytochemicals, and oxidative stressImmune cells in cancer

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Macrophage-derived extracellular succinate licenses neural stem cells to suppress chronic neuroinflammation

Peruzzotti-Jametti, L., Bernstock, J. D., Vicario, N., Costa, A. S. H., Kwok, C. K., Leonardi, T., Booty, L. M., Bicci, I., Balzarotti, B., Volpe, G., et al. (2018) · Cell Stem Cell

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

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Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses

Dugourd, A., Kuppe, C., Sciacovelli, M., Gjerga, E., Gabor, A., Emdal, K. B., Vieira, V., Bekker‐Jensen, D. B., Kranz, J., Bindels, E. M. J., et al. (2021) · Molecular Systems Biology

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

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Extracellular vesicles are independent metabolic units with asparaginase activity

Iraci, N., Gaude, E., Leonardi, T., Costa, A. S. H., Cossetti, C., Peruzzotti-Jametti, L., Bernstock, J. D., Saini, H. K., Gelati, M., Vescovi, A. L., et al. (2017) · Nature Chemical Biology

Extracellular vesicles in diseaseAmino Acid Enzymes and Metabolism

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Monitoring of physiological and blood parameters during perinatal and neonatal period in calves

Piccione, G., Casella, S., Pennisi, P., Giannetto, C., Costa, A., & Caola, G. (2010) · Arquivo Brasileiro de Medicina Veterinária e Zootecnia

Animal health and immunologyReproductive Physiology in Livestock

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Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

Kohlhauer, M., Dawkins, S., Costa, A. S. H., Lee, R., Young, T., Pell, V. R., Choudhury, R. P., Banning, A. P., Kharbanda, R. K., Study, O. A. M. I. (., et al. (2018) · Journal of the American Heart Association

Cardiac Ischemia and ReperfusionAcute Myocardial Infarction Research

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Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation

Johnson, T. I., Costa, A. S. H., Ferguson, A. N., & Frezza, C. (2018) · Cell Death & Disease

DNA Repair MechanismsEffects of Radiation Exposure

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