Holt, Ian J.

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

Reijns, M. A. M., Rabe, B., Rigby, R. E., Mill, P., Astell, K. R., Lettice, L. A., Boyle, S., Leitch, A., Keighren, M., Kilanowski, F., et al. (2012) · Cell

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 466

Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number

Tyynismaa, H., Sembongi, H., Bokori-Brown, M., Granycome, C., Ashley, N., Poulton, J., Jalanko, A., Spelbrink, J. N., Holt, I. J., & Suomalainen, A. (2004) · Human Molecular Genetics

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 250

Genetic heterogeneity and mitochondrial DNA heteroplasmy in Leber's hereditary optic neuropathy.

Holt, I. J., Miller, D. H., & Harding, A. E. (1989) · Journal of Medical Genetics

Mitochondrial Function and PathologyHereditary Neurological Disorders

Cited by 159

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks

Pohjoismäki, J. L. O., Goffart, S., Tyynismaa, H., Willcox, S., Ide, T., Kang, D., Suomalainen, A., Karhunen, P. J., Griffith, J. D., Holt, I. J., et al. (2009) · Journal of Biological Chemistry

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 122

Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA

Malena, A., Loro, E., Di Re, M., Holt, I. J., & Vergani, L. (2009) · Human Molecular Genetics

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 107

Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis

Johnson, M. A., Vidoni, S., Durigon, R., Pearce, S. F., Rorbach, J., He, J., Brea-Calvo, G., Minczuk, M., Reyes, A., Holt, I. J., et al. (2014) · PLoS ONE

Autophagy in Disease and TherapyPI3K/AKT/mTOR signaling in cancer

Cited by 63

Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction

Lee, S., Munoz-Oreja, M., Villar-Fernandez, M., Goicoechea-Barrenechea, L., Fernandez-Pelayo, U., Perez-Rodriguez, D., Gegg, M., de Arbina, A. L., Spinazzola, A., & Holt, I. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory)

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 0