Hoffman, Brad E.

High-efficiency transduction and correction of murine hemophilia b using AAV2 vectors devoid of multiple surface-exposed tyrosines

Markusic, D. M., Herzog, R. W., Aslanidi, G. V., Hoffman, B. E., Li, B., Li, M., Jayandharan, G. R., Ling, C., Zolotukhin, I., Ma, W., et al. (2010) · Molecular Therapy

Virus-based gene therapy researchHemophilia Treatment and Research

Cited by 131

Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells

Rogers, G. L., Shirley, J. L., Zolotukhin, I., Kumar, S. R. P., Sherman, A., Perrin, G. Q., Hoffman, B. E., Srivastava, A., Basner-Tschakarjan, E., Wallet, M. A., et al. (2017) · Blood

Immunotherapy and Immune ResponsesVirus-based gene therapy research

Cited by 131

Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies

Markusic, D. M., Hoffman, B. E., Perrin, G. Q., Nayak, S., Wang, X., LoDuca, P. A., High, K. A., & Herzog, R. W. (2013) · EMBO Molecular Medicine

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 116

Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid

Vercauteren, K., Hoffman, B. E., Zolotukhin, I., Keeler, G. D., Xiao, J. W., Basner-Tschakarjan, E., High, K. A., Ertl, H. C., Rice, C. M., Srivastava, A., et al. (2016) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 114

Impact of the Underlying Mutation and the Route of Vector Administration on Immune Responses to Factor IX in Gene Therapy for Hemophilia B

Cao, O., Hoffman, B. E., Moghimi, B., Nayak, S., Cooper, M., Zhou, S., Ertl, H. C., High, K. A., & Herzog, R. W. (2009) · Molecular Therapy

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 92

The Balance between CD8(+) T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose

Kumar, S. R. P., Hoffman, B. E., Terhorst, C., de Jong, Y. P., & Herzog, R. W. (2017) · Molecular Therapy

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 83

Liver induced transgene tolerance with AAV vectors

Keeler, G. D., Markusic, D. M., & Hoffman, B. E. (2019) · Cellular Immunology

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 81

Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells

Shirley, J. L., Keeler, G. D., Sherman, A., Zolotukhin, I., Markusic, D. M., Hoffman, B. E., Morel, L. M., Wallet, M. A., Terhorst, C., & Herzog, R. W. (2020) · Molecular Therapy

Immunotherapy and Immune ResponsesVirus-based gene therapy research

Cited by 79

Nonredundant Roles of IL-10 and TGF-β in Suppression of Immune Responses to Hepatic AAV-Factor IX Gene Transfer

Hoffman, B. E., Martino, A. T., Sack, B. K., Cao, O., Liao, G., Terhorst, C., & Herzog, R. W. (2011) · Molecular Therapy

Virus-based gene therapy researchT-cell and B-cell Immunology

Cited by 72

Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells

NAYAK, S., CAO, O., HOFFMAN, B. E., COOPER, M., ZHOU, S., ATKINSON, M. A., & HERZOG, R. W. (2009) · Journal of Thrombosis and Haemostasis

T-cell and B-cell ImmunologyHemophilia Treatment and Research

Cited by 66

Potential for cellular stress response to hepatic factor VIII expression from AAV vector

Zolotukhin, I., Markusic, D. M., Palaschak, B., Hoffman, B. E., Srikanthan, M. A., & Herzog, R. W. (2016) · Molecular Therapy - Methods & Clinical Development

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 65

Ex Vivo Expanded Autologous Polyclonal Regulatory T Cells Suppress Inhibitor Formation in Hemophilia

Sarkar, D., Biswas, M., Liao, G., Seay, H. R., Perrin, G. Q., Markusic, D. M., Hoffman, B. E., Brusko, T. M., Terhorst, C., & Herzog, R. W. (2014) · Molecular Therapy - Methods & Clinical Development

Hemophilia Treatment and ResearchT-cell and B-cell Immunology

Cited by 62

Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity

Martino, A. T., Nayak, S., Hoffman, B. E., Cooper, M., Liao, G., Markusic, D. M., Byrne, B. J., Terhorst, C., & Herzog, R. W. (2009) · PLoS ONE

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 54

Regulatory T cells and TLR9 activation shape antibody formation to a secreted transgene product in AAV muscle gene transfer

Herzog, R. W., Cooper, M., Perrin, G. Q., Biswas, M., Martino, A. T., Morel, L., Terhorst, C., & Hoffman, B. E. (2019) · Cellular Immunology

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 39