Leng, Kun

Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease

Leng, K., Li, E., Eser, R., Piergies, A., Sit, R., Tan, M., Neff, N., Li, S. H., Rodriguez, R. D., Suemoto, C. K., et al. (2021) · Nature Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 485

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Tian, R., Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Dräger, N., Leng, K., Nalls, M. A., Singleton, A. B., Xu, K., et al. (2020) · Nature Neuroscience

CRISPR and Genetic EngineeringFerroptosis and cancer prognosis

Cited by 414

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Tian, R., Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Dräger, N., Leng, K., Nalls, M. A., Singleton, A. B., Xu, K., et al. (2021) · Nature Neuroscience

CRISPR and Genetic EngineeringFerroptosis and cancer prognosis

Cited by 414

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

Dräger, N. M., Sattler, S. M., Huang, C. T.-L., Teter, O. M., Leng, K., Hashemi, S. H., Hong, J., Aviles, G., Clelland, C. D., Zhan, L., et al. (2022) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsPluripotent Stem Cells Research

Cited by 258

Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

Kim, H., Leng, K., Park, J., Sorets, A. G., Kim, S., Shostak, A., Embalabala, R. J., Mlouk, K., Katdare, K. A., Rose, I. V. L., et al. (2022) · Nature Communications

Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 201

Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology

de Majo, M., Koontz, M., Marsan, E., Salinas, N., Ramsey, A., Kuo, Y.-M., Seo, K., Li, H., Dräger, N., Leng, K., et al. (2023) · Stem Cell Reports

Amyotrophic Lateral Sclerosis ResearchPluripotent Stem Cells Research

Cited by 44

CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning

Teter, O. M., McQuade, A., Hagan, V., Liang, W., Dräger, N. M., Sattler, S. M., Holmes, B. B., Castillo, V. C., Papakis, V., Leng, K., et al. (2025) · Molecular Psychiatry

Neuroinflammation and Neurodegeneration MechanismsAutism Spectrum Disorder Research

Cited by 38