Rangaraju, Srikant

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Johnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,001

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Rangaraju, S., Dammer, E. B., Raza, S. A., Rathakrishnan, P., Xiao, H., Gao, T., Duong, D. M., Pennington, M. W., Lah, J. J., Seyfried, N. T., et al. (2018) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 430

Potassium Channel Kv1.3 Is Highly Expressed by Microglia in Human Alzheimer's Disease

Rangaraju, S., Gearing, M., Jin, L.-W., & Levey, A. (2015) · Journal of Alzheimer's Disease

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 137

Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes—Activation and Age-Related Effects

Rangaraju, S., Raza, S. A., Li, N. X., Betarbet, R., Dammer, E. B., Duong, D., Lah, J. J., Seyfried, N. T., & Levey, A. I. (2018) · Frontiers in Immunology

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 126

Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept

Maezawa, I., Nguyen, H. M., Di Lucente, J., Jenkins, D. P., Singh, V., Hilt, S., Kim, K., Rangaraju, S., Levey, A. I., Wulff, H., et al. (2018) · Brain

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 125

Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau

Rayaprolu, S., Higginbotham, L., Bagchi, P., Watson, C. M., Zhang, T., Levey, A. I., Rangaraju, S., & Seyfried, N. T. (2021) · Neuropsychopharmacology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 118

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis

Rangaraju, S., Chi, V., Pennington, M. W., & Chandy, K. G. (2009) · Expert Opinion on Therapeutic Targets

Ion channel regulation and functionMultiple Sclerosis Research Studies

Cited by 99

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

Rangaraju, S., Raza, S. A., Pennati, A., Deng, Q., Dammer, E. B., Duong, D., Pennington, M. W., Tansey, M. G., Lah, J. J., Betarbet, R., et al. (2017) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsIon channel regulation and function

Cited by 75

Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer’s disease

Rayaprolu, S., Gao, T., Xiao, H., Ramesha, S., Weinstock, L. D., Shah, J., Duong, D. M., Dammer, E. B., Webster, J. A., Lah, J. J., et al. (2019) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAdvanced Proteomics Techniques and Applications

Cited by 71

Prognostic Value of the 24-Hour Neurological Examination in Anterior Circulation Ischemic Stroke: A post hoc Analysis of Two Randomized Controlled Stroke Trials

Rangaraju, S., Frankel, M., & Jovin, T. G. (2015) · Interventional Neurology

Acute Ischemic Stroke ManagementStroke Rehabilitation and Recovery

Cited by 69

APOE expression and secretion are modulated by mitochondrial dysfunction

Wynne, M. E., Ogunbona, O., Lane, A. R., Gokhale, A., Zlatic, S. A., Xu, C., Wen, Z., Duong, D. M., Rayaprolu, S., Ivanova, A., et al. (2023) · eLife

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 35

Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology

Goettemoeller, A. M., Banks, E., Kumar, P., Olah, V. J., McCann, K. E., South, K., Ramelow, C. C., Eaton, A., Duong, D. M., Seyfried, N. T., et al. (2024) · Nature Communications

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 30

Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries

Pybus, A. F., Bitarafan, S., Brothers, R. O., Rohrer, A., Khaitan, A., Moctezuma, F. R., Udeshi, K., Davies, B., Triplett, S., Griffin, M. N., et al. (2024) · Journal of Neuroinflammation

Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular Disturbances

Cited by 12