Toledo, Luis I

ATR prohibits replication catastrophe by preventing global exhaustion of RPA

Toledo, L. I., Altmeyer, M., Rask, M.-B., Lukas, C., Larsen, D. H., Povlsen, L. K., Bekker-Jensen, S., Mailand, N., Bartek, J., & Lukas, J. (2013) · Cell

DNA Repair MechanismsTelomeres, Telomerase, and Senescence

Cited by 911

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

Toledo, L. I., Murga, M., Zur, R., Soria, R., Rodriguez, A., Martinez, S., Oyarzabal, J., Pastor, J., Bischoff, J. R., & Fernandez-Capetillo, O. (2011) · Nature Structural & Molecular Biology

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 465

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

Murga, M., Campaner, S., Lopez-Contreras, A. J., Toledo, L. I., Soria, R., Montaña, M. F., D'Artista, L., Schleker, T., Guerra, C., Garcia, E., et al. (2011) · Nature Structural & Molecular Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 381

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

Cuadrado, M., Martinez-Pastor, B., Murga, M., Toledo, L. I., Gutierrez-Martinez, P., Lopez, E., & Fernandez-Capetillo, O. (2006) · The Journal of Experimental Medicine

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 232

ATR signaling can drive cells into senescence in the absence of DNA breaks

Toledo, L. I., Murga, M., Gutierrez-Martinez, P., Soria, R., & Fernandez-Capetillo, O. (2008) · Genes & Development

DNA Repair MechanismsTelomeres, Telomerase, and Senescence

Cited by 183