Dick, Lawrence R.

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.

Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., & Goldberg, A. L. (1994) · Cell

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 2,524

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Soucy, T. A., Smith, P. G., Milhollen, M. A., Berger, A. J., Gavin, J. M., Adhikari, S., Brownell, J. E., Burke, K. E., Cardin, D. P., Critchley, S., et al. (2009) · Nature

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 1,990

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

Adams, J., Behnke, M., Chen, S., Cruickshank, A. A., Dick, L. R., Grenier, L., Klunder, J. M., Ma, Y.-T., Plamondon, L., & Stein, R. L. (1998) · Bioorganic & Medicinal Chemistry Letters

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 685

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

Bedford, L., Lowe, J., Dick, L. R., Mayer, R. J., & Brownell, J. E. (2011) · Nature Reviews Drug Discovery

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 563

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Hyer, M. L., Milhollen, M. A., Ciavarri, J., Fleming, P., Traore, T., Sappal, D., Huck, J., Shi, J., Gavin, J., Brownell, J., et al. (2018) · Nature Medicine

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 447

The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy

Soucy, T. A., Dick, L. R., Smith, P. G., Milhollen, M. A., & Brownell, J. E. (2010) · Genes & Cancer

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

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