Ohh, Michael

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science

Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathways

Cited by 4,735

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T.-Y., Huang, L. E., Pavletich, N., Chau, V., & Kaelin, W. G. (2000) · Nature Cell Biology

Ubiquitin and proteasome pathwaysCancer, Hypoxia, and Metabolism

Cited by 1,577

The updated biology of hypoxia-inducible factor

Greer, S. N., Metcalf, J. L., Wang, Y., & Ohh, M. (2012) · The EMBO Journal

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 545

Multiple Splice Variants of the Human HIF-3α Locus Are Targets of the von Hippel-Lindau E3 Ubiquitin Ligase Complex

Maynard, M. A., Qi, H., Chung, J., Lee, E. H. L., Kondo, Y., Hara, S., Conaway, R. C., Conaway, J. W., & Ohh, M. (2003) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathways

Cited by 283

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

Bunda, S., Burrell, K., Heir, P., Zeng, L., Alamsahebpour, A., Kano, Y., Raught, B., Zhang, Z.-Y., Zadeh, G., & Ohh, M. (2015) · Nature Communications

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 249

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Kano, Y., Gebregiworgis, T., Marshall, C. B., Radulovich, N., Poon, B. P. K., St-Germain, J., Cook, J. D., Valencia-Sama, I., Grant, B. M. M., Herrera, S. G., et al. (2019) · Nature Communications

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 103

Suppression of Hypoxia-Inducible Factor 2α Restores p53 Activity via Hdm2 and Reverses Chemoresistance of Renal Carcinoma Cells

Roberts, A. M., Watson, I. R., Evans, A. J., Foster, D. A., Irwin, M. S., & Ohh, M. (2009) · Cancer Research

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 88

NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS–MAPK Pathway in Neuroblastoma

Valencia-Sama, I., Ladumor, Y., Kee, L., Adderley, T., Christopher, G., Robinson, C. M., Kano, Y., Ohh, M., & Irwin, M. S. (2020) · Cancer Research

Neuroblastoma Research and TreatmentsProtein Tyrosine Phosphatases

Cited by 62

The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors

Gebregiworgis, T., Kano, Y., St-Germain, J., Radulovich, N., Udaskin, M. L., Mentes, A., Huang, R., Poon, B. P. K., He, W., Valencia-Sama, I., et al. (2021) · Nature Communications

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 49

New structural and functional insight into the regulation of Ras

Kano, Y., Cook, J. D., Lee, J. E., & Ohh, M. (2016) · Seminars in Cell & Developmental Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 38

Consequences of VHL Loss on Global DNA Methylome

Robinson, C. M., Lefebvre, F., Poon, B. P., Bousard, A., Fan, X., Lathrop, M., Tost, J., Kim, W. Y., Riazalhosseini, Y., & Ohh, M. (2018) · Scientific Reports

Epigenetics and DNA MethylationCancer, Hypoxia, and Metabolism

Cited by 21

Molecular Cloning and Characterization of the von Hippel-Lindau-Like Protein

Qi, H., Gervais, M. L., Li, W., DeCaprio, J. A., Challis, J. R. G., & Ohh, M. (2004) · Molecular Cancer Research

Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathways

Cited by 16