Stoffel, Markus

Combinatorial microRNA target predictions

Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 4,603

Silencing of microRNAs in vivo with ‘antagomirs’

Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature

MicroRNA in disease regulationRNA Interference and Gene Delivery

Cited by 3,949

A pancreatic islet-specific microRNA regulates insulin secretion

Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature

Pancreatic function and diabetesMicroRNA in disease regulation

Cited by 2,102

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics

Regulation of Appetite and ObesityCytokine Signaling Pathways and Interactions

Cited by 1,086

MicroRNAs 103 and 107 regulate insulin sensitivity

Trajkovski, M., Hausser, J., Soutschek, J., Bhat, B., Akin, A., Zavolan, M., Heim, M. H., & Stoffel, M. (2011) · Nature

MicroRNA in disease regulationMetabolism, Diabetes, and Cancer

Cited by 1,000

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

Wolfrum, C., Shi, S., Jayaprakash, K. N., Jayaraman, M., Wang, G., Pandey, R. K., Rajeev, K. G., Nakayama, T., Charrise, K., Ndungo, E. M., et al. (2007) · Nature Biotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 974

A skin microRNA promotes differentiation by repressing ‘stemness’

Yi, R., Poy, M. N., Stoffel, M., & Fuchs, E. (2008) · Nature

MicroRNA in disease regulationHair Growth and Disorders

Cited by 790

miR-375 maintains normal pancreatic α- and β-cell mass

Poy, M. N., Hausser, J., Trajkovski, M., Braun, M., Collins, S., Rorsman, P., Zavolan, M., & Stoffel, M. (2009) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesMicroRNA in disease regulation

Cited by 740

Whole population, genome-wide mapping of hidden relatedness

Gusev, A., Lowe, J. K., Stoffel, M., Daly, M. J., Altshuler, D., Breslow, J. L., Friedman, J. M., & Pe'er, I. (2009) · Genome Research

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 450

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Rothgangl, T., Dennis, M. K., Lin, P. J. C., Oka, R., Witzigmann, D., Villiger, L., Qi, W., Hruzova, M., Kissling, L., Lenggenhager, D., et al. (2021) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 378

Impact of MicroRNA levels, target-site complementarity, and cooperativity on competing endogenous RNA-regulated gene expression

Denzler, R., McGeary, S. E., Title, A. C., Agarwal, V., Bartel, D. P., & Stoffel, M. (2016) · Molecular Cell

Cancer-related molecular mechanisms researchMicroRNA in disease regulation

Cited by 340

MicroRNA-7a regulates pancreatic β cell function

Latreille, M., Hausser, J., Stützer, I., Zhang, Q., Hastoy, B., Gargani, S., Kerr-Conte, J., Pattou, F., Zavolan, M., Esguerra, J. L. S., et al. (2014) · Journal of Clinical Investigation

Pancreatic function and diabetesMicroRNA in disease regulation

Cited by 281

DGCR8-dependent microRNA biogenesis is essential for skin development

Yi, R., Pasolli, H. A., Landthaler, M., Hafner, M., Ojo, T., Sheridan, R., Sander, C., O'Carroll, D., Stoffel, M., Tuschl, T., et al. (2009) · Proceedings of the National Academy of Sciences

MicroRNA in disease regulationDevelopmental Biology and Gene Regulation

Cited by 232

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

Otani, K., Kulkarni, R. N., Baldwin, A. C., Krutzfeldt, J., Ueki, K., Stoffel, M., Kahn, C. R., & Polonsky, K. S. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 185

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

Villiger, L., Rothgangl, T., Witzigmann, D., Oka, R., Lin, P. J. C., Qi, W., Janjuha, S., Berk, C., Ringnalda, F., Beattie, M. B., et al. (2021) · Nature Biomedical Engineering

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 105

Therapeutic RNA-silencing oligonucleotides in metabolic diseases

Goga, A., & Stoffel, M. (2022) · Nature Reviews Drug Discovery

RNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry

Cited by 58

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

Mobin, M. B., Gerstberger, S., Teupser, D., Campana, B., Charisse, K., Heim, M. H., Manoharan, M., Tuschl, T., & Stoffel, M. (2016) · Nature Communications

RNA Research and SplicingCholesterol and Lipid Metabolism

Cited by 55

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling

Scoyni, F., Sitnikova, V., Giudice, L., Korhonen, P., Trevisan, D. M., Hernandez de Sande, A., Gomez-Budia, M., Giniatullina, R., Ugidos, I. F., Dhungana, H., et al. (2024) · Cell Reports

Circular RNAs in diseasesMicroRNA in disease regulation

Cited by 27