Sierksma, Annerieke

Alteration of the microRNA network during the progression of Alzheimer's disease

Lau, P., Bossers, K., Janky, R., Salta, E., Frigerio, C. S., Barbash, S., Rothman, R., Sierksma, A. S. R., Thathiah, A., Greenberg, D., et al. (2013) · EMBO Molecular Medicine

MicroRNA in disease regulationAlzheimer's disease research and treatments

Cited by 474

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

De Schepper, S., Ge, J. Z., Sierksma, A., Crowley, G., Ferreira, L. S. S., Garceau, D., Toomey, C. E., Sokolova, D., Rueda-Carrasco, J., Shin, S.-H., et al. (2023) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 295

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

Mancuso, R., Van Den Daele, J., Fattorelli, N., Wolfs, L., Balusu, S., Burton, O., Liston, A., Sierksma, A., Fourne, Y., Poovathingal, S., et al. (2019) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 295

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

Sierksma, A., Lu, A., Mancuso, R., Fattorelli, N., Thrupp, N., Salta, E., Zoco, J., Blum, D., Buée, L., De Strooper, B., et al. (2020) · EMBO Molecular Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 291

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

Salta, E., Sierksma, A., Vanden Eynden, E., & De Strooper, B. (2016) · EMBO Molecular Medicine

Alzheimer's disease research and treatmentsMicroRNA in disease regulation

Cited by 169

Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link?

Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M., & Prickaerts, J. (2010) · European Journal of Pharmacology

Dementia and Cognitive Impairment ResearchStress Responses and Cortisol

Cited by 139

Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

Sierksma, A., Lu, A., Salta, E., Vanden Eynden, E., Callaerts-Vegh, Z., D’Hooge, R., Blum, D., Buée, L., Fiers, M., & De Strooper, B. (2018) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsMicroRNA in disease regulation

Cited by 120

Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s disease

Lemmens, M. A. M., Sierksma, A. S. R., Rutten, B. P. F., Dennissen, F., Steinbusch, H. W. M., Lucassen, P. J., & Schmitz, C. (2011) · Brain Structure and Function

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 37