Swanton, Charles

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

Dentro, S. C., Leshchiner, I., Haase, K., Tarabichi, M., Wintersinger, J., Deshwar, A. G., Yu, K., Rubanova, Y., Macintyre, G., Demeulemeester, J., et al. (2021) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 533

Targeted therapy for advanced solid tumors on the basis of molecular profiles: Results from MyPathway, an open-label, phase IIa multiple basket study

Hainsworth, J. D., Meric-Bernstam, F., Swanton, C., Hurwitz, H., Spigel, D. R., Sweeney, C., Burris, H. A., Bose, R., Yoo, B., Stein, A., et al. (2018) · Journal of Clinical Oncology

Lung Cancer Treatments and MutationsCancer Genomics and Diagnostics

Cited by 506

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination

Wall, E. C., Wu, M., Harvey, R., Kelly, G., Warchal, S., Sawyer, C., Daniels, R., Hobson, P., Hatipoglu, E., Ngai, Y., et al. (2021) · The Lancet

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 491

Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

Abbosh, C., Frankell, A. M., Harrison, T., Kisistok, J., Garnett, A., Johnson, L., Veeriah, S., Moreau, M., Chesh, A., Chaunzwa, T. L., et al. (2023) · Nature

Cancer Genomics and DiagnosticsLung Cancer Diagnosis and Treatment

Cited by 382

Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis

Li, J., Duran, M. A., Dhanota, N., Chatila, W. K., Bettigole, S. E., Kwon, J., Sriram, R. K., Humphries, M. P., Salto-Tellez, M., James, J. A., et al. (2021) · Cancer Discovery

Adenosine and Purinergic SignalingCancer Immunotherapy and Biomarkers

Cited by 312

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Woodcock, H. V., Eley, J. D., Guillotin, D., Platé, M., Nanthakumar, C. B., Martufi, M., Peace, S., Joberty, G., Poeckel, D., Good, R. B., et al. (2019) · Nature Communications

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPI3K/AKT/mTOR signaling in cancer

Cited by 224

Selection of metastasis competent subclones in the tumour interior

Zhao, Y., Fu, X., Lopez, J. I., Rowan, A., Au, L., Fendler, A., Hazell, S., Xu, H., Horswell, S., Shepherd, S. T. C., et al. (2021) · Nature Ecology & Evolution

Cancer Genomics and DiagnosticsCancer Cells and Metastasis

Cited by 95

Prevalence of clonal hematopoiesis of indeterminate potential (CHIP) measured by an ultra-sensitive sequencing assay: Exploratory analysis of the Circulating Cancer Genome Atlas (CCGA) study.

Swanton, C., Venn, O., Aravanis, A., Hubbell, E., Maddala, T., Beausang, J. F., Filippova, D., Gross, S., Jamshidi, A., Shen, L., et al. (2018) · Journal of Clinical Oncology

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

Cited by 57

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

Faulkner, N., Ng, K. W., Wu, M. Y., Harvey, R., Margaritis, M., Paraskevopoulou, S., Houlihan, C., Hussain, S., Greco, M., Bolland, W., et al. (2021) · eLife

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 52

Unintended on-target chromosomal instability following CRISPR/Cas9 single gene targeting

Przewrocka, J., Rowan, A., Rosenthal, R., Kanu, N., & Swanton, C. (2020) · Annals of Oncology

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 33

A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer

Middleton, G., Robbins, H. L., Fletcher, P., Savage, J., Mehmi, M., Summers, Y., Greystoke, A., Steele, N., Popat, S., Jain, P., et al. (2025) · npj Precision Oncology

Lung Cancer Treatments and MutationsPI3K/AKT/mTOR signaling in cancer

Cited by 7