Fasching, Bernhard

From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation

Oleinikovas, V., Gainza, P., Ryckmans, T., Fasching, B., & Thomä, N. H. (2024) · Annual Review of Pharmacology and Toxicology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

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Mining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition

Petzold, G., Gainza, P., Annunziato, S., Lamberto, I., Trenh, P., McAllister, L. A., DeMarco, B., Schwander, L., Bunker, R. D., Zlotosch, M., et al. (2025) · Science

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 117

Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition

Petzold, G., Gainza, P., Annunziato, S., Lamberto, I., Trenh, P., McAllister, L., Demarco, B., Schwander, L., Bunker, R. D., Zlotosch, M., et al. (2024) · Science

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 117

Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry

Annunziato, S., Quan, C., Donckele, E. J., Lamberto, I., Bunker, R. D., Zlotosch, M., Schwander, L., Murthy, A., Wiedmer, L., Staehly, C., et al. (2026) · Nature Structural & Molecular Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 9