Ratan, Rajiv R.

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

Lehnardt, S., Massillon, L., Follett, P., Jensen, F. E., Ratan, R., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. (2003) · Proceedings of the National Academy of Sciences

Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Cited by 1,052

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

Sleiman, S. F., Henry, J., Al-Haddad, R., El Hayek, L., Abou Haidar, E., Stringer, T., Ulja, D., Karuppagounder, S. S., Holson, E. B., Ratan, R. R., et al. (2016) · eLife

Nerve injury and regenerationNeuroscience and Neuropharmacology Research

Cited by 810

HDAC6 is a target for protection and regeneration following injury in the nervous system

Rivieccio, M. A., Brochier, C., Willis, D. E., Walker, B. A., D'Annibale, M. A., McLaughlin, K., Siddiq, A., Kozikowski, A. P., Jaffrey, S. R., Twiss, J. L., et al. (2009) · Proceedings of the National Academy of Sciences

Histone Deacetylase Inhibitors ResearchNerve injury and regeneration

Cited by 322

Tau Activation of Microglial cGAS–IFN Reduces MEF2C‐mediated Cognitive Resilience

Udeochu, J. C., Amin, S., Huang, Y., Fan, L., Torres, E. R. S., Carling, G. K., Liu, B., McGurran, H., Coronas-Samano, G., Kauwe, G., et al. (2023) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 289

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

Lange, P. S., Chavez, J. C., Pinto, J. T., Coppola, G., Sun, C.-W., Townes, T. M., Geschwind, D. H., & Ratan, R. R. (2008) · The Journal of Experimental Medicine

Endoplasmic Reticulum Stress and DiseaseRedox biology and oxidative stress

Cited by 272

Oxidative Stress and Huntington’s Disease: The Good, the Bad, and the Ugly

Kumar, A., & Ratan, R. R. (2016) · Journal of Huntington s Disease

Genetic Neurodegenerative DiseasesRedox biology and oxidative stress

Cited by 236

The role of iron neurotoxicity in ischemic stroke

Selim, M. H., & Ratan, R. R. (2004) · Ageing Research Reviews

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 158

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

Karuppagounder, S. S., Alim, I., Khim, S. J., Bourassa, M. W., Sleiman, S. F., John, R., Thinnes, C. C., Yeh, T.-L., Demetriades, M., Neitemeier, S., et al. (2016) · Science Translational Medicine

Intracerebral and Subarachnoid Hemorrhage ResearchNeonatal and fetal brain pathology

Cited by 141

Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

Carling, G. K., Fan, L., Foxe, N. R., Norman, K., Wong, M. Y., Zhu, D., Corona, C., Razzoli, A., Yu, F., Yarahmady, A., et al. (2024) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 89

2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience

Kumar, A., Karuppagounder, S. S., Chen, Y., Corona, C., Kawaguchi, R., Cheng, Y., Balkaya, M., Sagdullaev, B. T., Wen, Z., Stuart, C., et al. (2023) · Neuron

Endoplasmic Reticulum Stress and DiseaseDietary Effects on Health

Cited by 64

HIF1α stabilization in hypoxia is not oxidant-initiated

Kumar, A., Vaish, M., Karuppagounder, S. S., Gazaryan, I., Cave, J. W., Starkov, A. A., Anderson, E. T., Zhang, S., Pinto, J. T., Rountree, A. M., et al. (2021) · eLife

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 34