Saltiel, Alan R.

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 5,326

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancer

Cited by 4,664

Inflammatory links between obesity and metabolic disease

Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 2,319

Inflammatory mechanisms linking obesity and metabolic disease

Saltiel, A. R., & Olefsky, J. M. (2017) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 2,212

Adapting to obesity with adipose tissue inflammation

Reilly, S. M., & Saltiel, A. R. (2017) · Nature Reviews Endocrinology

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 1,204

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

Lumeng, C. N., DeYoung, S. M., Bodzin, J. L., & Saltiel, A. R. (2007) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 1,016

Signaling pathways in insulin action: molecular targets of insulin resistance

Pessin, J. E., & Saltiel, A. R. (2000) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 939

Regulation of glucose transport by insulin: traffic control of GLUT4

Leto, D., & Saltiel, A. R. (2012) · Nature Reviews Molecular Cell Biology

Cellular transport and secretionMetabolism, Diabetes, and Cancer

Cited by 848

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Fang, S., Suh, J. M., Reilly, S. M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., et al. (2015) · Nature Medicine

Adipose Tissue and MetabolismDrug Transport and Resistance Mechanisms

Cited by 738

Insulin signaling in health and disease

Saltiel, A. R. (2021) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 446

Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin

Lazar, D. F., Wiese, R. J., Brady, M. J., Mastick, C. C., Waters, S. B., Yamauchi, K., Pessin, J. E., Cuatrecasas, P., & Saltiel, A. R. (1995) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

Cited by 396

A Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue

Chun, T.-H., Hotary, K. B., Sabeh, F., Saltiel, A. R., Allen, E. D., & Weiss, S. J. (2006) · Cell

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 378

Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins

Lumeng, C. N., Deyoung, S. M., & Saltiel, A. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 359

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

Kim, J. Y., Garcia-Carbonell, R., Yamachika, S., Zhao, P., Dhar, D., Loomba, R., Kaufman, R. J., Saltiel, A. R., & Karin, M. (2018) · Cell

Liver Disease Diagnosis and TreatmentEndoplasmic Reticulum Stress and Disease

Cited by 333

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Barrett, S. D., Bridges, A. J., Dudley, D. T., Saltiel, A. R., Fergus, J. H., Flamme, C. M., Delaney, A. M., Kaufman, M., LePage, S., Leopold, W. R., et al. (2008) · Bioorganic & Medicinal Chemistry Letters

Melanoma and MAPK PathwaysHeterocyclic Compound Synthesis and Bioactivity

Cited by 289

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling

Yamauchi, K., Milarski, K. L., Saltiel, A. R., & Pessin, J. E. (1995) · Proceedings of the National Academy of Sciences

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 263

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

Ma, H.-Y., Yamamoto, G., Xu, J., Liu, X., Karin, D., Kim, J. Y., Alexandrov, L. B., Koyama, Y., Nishio, T., Benner, C., et al. (2020) · Journal of Hepatology

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 216

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.

Newgard, C. B., Brady, M. J., O'Doherty, R. M., & Saltiel, A. R. (2000) · Diabetes

Glycogen Storage Diseases and MyoclonusMetabolism, Diabetes, and Cancer

Cited by 189

Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation

Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T. E., Qian, J., Hung, C.-W., Zhao, P., Jones, Y., Gao, H., et al. (2024) · Nature Metabolism

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 176

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

Chen, X.-W., Leto, D., Xiong, T., Yu, G., Cheng, A., Decker, S., & Saltiel, A. R. (2011) · Molecular Biology of the Cell

Cellular transport and secretionMetabolism, Diabetes, and Cancer

Cited by 108

Exocyst function regulated by effector phosphorylation

Chen, X.-W., Leto, D., Xiao, J., Goss, J., Wang, Q., Shavit, J. A., Xiong, T., Yu, G., Ginsburg, D., Toomre, D., et al. (2011) · Nature Cell Biology

Cellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Cited by 76

p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity

Baeza-Raja, B., Li, P., Le Moan, N., Sachs, B. D., Schachtrup, C., Davalos, D., Vagena, E., Bridges, D., Kim, C., Saltiel, A. R., et al. (2012) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 53

RalA controls glucose homeostasis by regulating glucose uptake in brown fat

Skorobogatko, Y., Dragan, M., Cordon, C., Reilly, S. M., Hung, C.-W., Xia, W., Zhao, P., Wallace, M., Lackey, D. E., Chen, X.-W., et al. (2018) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 52

Bi-allelic Variants in RALGAPA1 Cause Profound Neurodevelopmental Disability, Muscular Hypotonia, Infantile Spasms, and Feeding Abnormalities

Wagner, M., Skorobogatko, Y., Pode-Shakked, B., Powell, C. M., Alhaddad, B., Seibt, A., Barel, O., Heimer, G., Hoffmann, C., Demmer, L. A., et al. (2020) · The American Journal of Human Genetics

Genetics and Neurodevelopmental DisordersProtein Kinase Regulation and GTPase Signaling

Cited by 31