Malani, Nirav

In vivo genome editing restores haemostasis in a mouse model of haemophilia

Li, H., Haurigot, V., Doyon, Y., Li, T., Wong, S. Y., Bhagwat, A. S., Malani, N., Anguela, X. M., Sharma, R., Ivanciu, L., et al. (2011) · Nature

Hemophilia Treatment and ResearchCRISPR and Genetic Engineering

Cited by 548

A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

Hacein-Bey-Abina, S., Pai, S.-Y., Gaspar, H. B., Armant, M., Berry, C. C., Blanche, S., Bleesing, J., Blondeau, J., de Boer, H., Buckland, K. F., et al. (2014) · New England Journal of Medicine

Virus-based gene therapy researchImmunodeficiency and Autoimmune Disorders

Cited by 412

HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2

Ocwieja, K. E., Brady, T. L., Ronen, K., Huegel, A., Roth, S. L., Schaller, T., James, L. C., Towers, G. J., Young, J. A. T., Chanda, S. K., et al. (2011) · PLoS Pathogens

HIV Research and TreatmentVirus-based gene therapy research

Cited by 212

BET proteins promote efficient murine leukemia virus integration at transcription start sites

Sharma, A., Larue, R. C., Plumb, M. R., Malani, N., Male, F., Slaughter, A., Kessl, J. J., Shkriabai, N., Coward, E., Aiyer, S. S., et al. (2013) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchProtein Degradation and Inhibitors

Cited by 193

The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites

De Rijck, J., de Kogel, C., Demeulemeester, J., Vets, S., El Ashkar, S., Malani, N., Bushman, F. D., Landuyt, B., Husson, S. J., Busschots, K., et al. (2013) · Cell Reports

Virus-based gene therapy researchProtein Degradation and Inhibitors

Cited by 175

A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase

Sharma, A., Slaughter, A., Jena, N., Feng, L., Kessl, J. J., Fadel, H. J., Malani, N., Male, F., Wu, L., Poeschla, E., et al. (2014) · PLoS Pathogens

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 124

Allosteric Inhibition of Human Immunodeficiency Virus Integrase

Gupta, K., Brady, T., Dyer, B. M., Malani, N., Hwang, Y., Male, F., Nolte, R. T., Wang, L., Velthuisen, E., Jeffrey, J., et al. (2014) · Journal of Biological Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 81

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

Aiyer, S., Swapna, G. V. T., Malani, N., Aramini, J. M., Schneider, W. M., Plumb, M. R., Ghanem, M., Larue, R. C., Sharma, A., Studamire, B., et al. (2014) · Nucleic Acids Research

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 72

Gammaretroviral Integration into Nucleosomal Target DNA In Vivo

Roth, S. L., Malani, N., & Bushman, F. D. (2011) · Journal of Virology

Virus-based gene therapy researchGenomics and Chromatin Dynamics

Cited by 69

Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag

Schneider, W. M., Brzezinski, J. D., Aiyer, S., Malani, N., Gyuricza, M., Bushman, F. D., & Roth, M. J. (2013) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentT-cell and Retrovirus Studies

Cited by 49

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes

Larue, R. C., Plumb, M. R., Crowe, B. L., Shkriabai, N., Sharma, A., DiFiore, J., Malani, N., Aiyer, S. S., Roth, M. J., Bushman, F. D., et al. (2014) · Nucleic Acids Research

Virus-based gene therapy researchProtein Degradation and Inhibitors

Cited by 44

Structural and sequencing analysis of local target DNA recognition by MLV integrase

Aiyer, S., Rossi, P., Malani, N., Schneider, W. M., Chandar, A., Bushman, F. D., Montelione, G. T., & Roth, M. J. (2015) · Nucleic Acids Research

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 25