Vekrellis, Kostas

Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., & Vekrellis, K. (2010) · The Journal of Neuroscience

Parkinson's Disease Mechanisms and TreatmentsExtracellular vesicles in disease

Cited by 1,115

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

Vogiatzi, T., Xilouri, M., Vekrellis, K., & Stefanis, L. (2008) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 683

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

Minakaki, G., Menges, S., Kittel, A., Emmanouilidou, E., Schaeffner, I., Barkovits, K., Bergmann, A., Rockenstein, E., Adame, A., Marxreiter, F., et al. (2018) · Autophagy

Parkinson's Disease Mechanisms and TreatmentsExtracellular vesicles in disease

Cited by 272

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

Papadakis, M., Hadley, G., Xilouri, M., Hoyte, L. C., Nagel, S., McMenamin, M. M., Tsaknakis, G., Watt, S. M., Drakesmith, C. W., Chen, R., et al. (2013) · Nature Medicine

Autophagy in Disease and TherapyNeurological Disease Mechanisms and Treatments

Cited by 232

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

Ghanem, S. S., Majbour, N. K., Vaikath, N. N., Ardah, M. T., Erskine, D., Jensen, N. M., Fayyad, M., Sudhakaran, I. P., Vasili, E., Melachroinou, K., et al. (2022) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 191

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

Emmanouilidou, E., Elenis, D., Papasilekas, T., Stranjalis, G., Gerozissis, K., Ioannou, P. C., & Vekrellis, K. (2011) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 163

Endogenous Alpha-Synuclein is Essential for the Transfer of Pathology by Exosome-Enriched Extracellular Vesicles, Following Inoculation with Preformed Fibrils in vivo

Melachroinou, K., Divolis, G., Tsafaras, G., Karampetsou, M., Fortis, S. P., Stratoulias, Y., Papadopoulou, G., Kriebardis, A. G., Samiotaki, M. K., & Vekrellis, K. (2024) · aging and disease

Parkinson's Disease Mechanisms and TreatmentsExtracellular vesicles in disease

Cited by 9