Matreyek, Kenneth A.

Multiplex assessment of protein variant abundance by massively parallel sequencing

Matreyek, K. A., Starita, L. M., Stephany, J. J., Martin, B., Chiasson, M. A., Gray, V. E., Kircher, M., Khechaduri, A., Dines, J. N., Hause, R. J., et al. (2018) · Nature Genetics

Genomics and Rare DiseasesCancer Genomics and Diagnostics

Cited by 436

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

Matreyek, K. A., Yücel, S. S., Li, X., & Engelman, A. (2013) · PLoS Pathogens

HIV Research and TreatmentNuclear Structure and Function

Cited by 280

On the design of CRISPR-based single-cell molecular screens

Hill, A. J., McFaline-Figueroa, J. L., Starita, L. M., Gasperini, M. J., Matreyek, K. A., Packer, J., Jackson, D., Shendure, J., & Trapnell, C. (2018) · Nature Methods

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 262

An improved platform for functional assessment of large protein libraries in mammalian cells

Matreyek, K. A., Stephany, J. J., Chiasson, M. A., Hasle, N., & Fowler, D. M. (2019) · Nucleic Acids Research

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 122

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration

Koh, Y., Wu, X., Ferris, A. L., Matreyek, K. A., Smith, S. J., Lee, K., KewalRamani, V. N., Hughes, S. H., & Engelman, A. (2013) · Journal of Virology

HIV Research and TreatmentVirus-based gene therapy research

Cited by 122

Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity

Suiter, C. C., Moriyama, T., Matreyek, K. A., Yang, W., Scaletti, E. R., Nishii, R., Yang, W., Hoshitsuki, K., Singh, M., Trehan, A., et al. (2020) · Proceedings of the National Academy of Sciences

Pharmacogenetics and Drug MetabolismGenomics and Rare Diseases

Cited by 121

Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers

Matreyek, K. A., Stephany, J. J., Ahler, E., & Fowler, D. M. (2021) · Genome Medicine

PI3K/AKT/mTOR signaling in cancerCancer Genomics and Diagnostics

Cited by 48

Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors

Koh, Y., Matreyek, K. A., & Engelman, A. (2011) · Journal of Virology

HIV/AIDS drug development and treatmentVirus-based gene therapy research

Cited by 37

Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance

Aslanzadeh, V., Brierley, G. V., Kumar, R., Çubuk, H., Vigouroux, C., Matreyek, K. A., Kudla, G., & Semple, R. K. (2025) · Nature Communications

Genomics and Rare DiseasesPancreatic function and diabetes

Cited by 15