Donohoue, Paul D.

Mapping the genomic landscape of CRISPR-Cas9 cleavage

Cameron, P., Fuller, C. K., Donohoue, P. D., Jones, B. N., Thompson, M. S., Carter, M. M., Gradia, S., Vidal, B., Garner, E., Slorach, E. M., et al. (2017) · Nature Methods

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 443

Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform

Enquist-Newman, M., Faust, A. M. E., Bravo, D. D., Santos, C. N. S., Raisner, R. M., Hanel, A., Sarvabhowman, P., Le, C., Regitsky, D. D., Cooper, S. R., et al. (2014) · Nature

Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversion

Cited by 351

Structural basis for Cas9 off-target activity

Pacesa, M., Lin, C.-H., Cléry, A., Saha, A., Arantes, P. R., Bargsten, K., Irby, M. J., Allain, F. H.-T., Palermo, G., Cameron, P., et al. (2022) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 198

Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells

Donohoue, P. D., Pacesa, M., Lau, E., Vidal, B., Irby, M. J., Nyer, D. B., Rotstein, T., Banh, L., Toh, M. S., Gibson, J., et al. (2021) · Molecular Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 69