McGowan, Sara J.

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell

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Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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An aged immune system drives senescence and ageing of solid organs

Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K.-A., McGowan, S. J., et al. (2021) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., et al. (2017) · Nature Communications

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

Yousefzadeh, M. J., Zhao, J., Bukata, C., Wade, E. A., McGowan, S. J., Angelini, L. A., Bank, M. P., Gurkar, A. U., McGuckian, C. A., Calubag, M. F., et al. (2020) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., et al. (2018) · Redox Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging

Dorronsoro, A., Santiago, F. E., Grassi, D., Zhang, T., Lai, R. C., McGowan, S. J., Angelini, L., Lavasani, M., Corbo, L., Lu, A., et al. (2021) · Aging Cell

Telomeres, Telomerase, and SenescenceMesenchymal stem cell research

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ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

Zhao, J., Zhang, L., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X., Gurkar, A. U., et al. (2020) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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