Ueffing, Marius

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

Achberger, K., Probst, C., Haderspeck, J., Bolz, S., Rogal, J., Chuchuy, J., Nikolova, M., Cora, V., Antkowiak, L., Haq, W., et al. (2019) · eLife

Retinal Development and Disorders3D Printing in Biomedical Research

Cited by 380

Mechanism of inhibition of Raf-1 by protein kinase A

Häfner, S., Adler, H. S., Mischak, H., Janosch, P., Heidecker, G., Wolfman, A., Pippig, S., Lohse, M., Ueffing, M., & Kolch, W. (1994) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 312

The complement system in age-related macular degeneration

Armento, A., Ueffing, M., & Clark, S. J. (2021) · Cellular and Molecular Life Sciences

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 258

A new perspective on lipid research in age-related macular degeneration

van Leeuwen, E. M., Emri, E., Merle, B. M. J., Colijn, J. M., Kersten, E., Cougnard-Gregoire, A., Dammeier, S., Meester-Smoor, M., Pool, F. M., de Jong, E. K., et al. (2018) · Progress in Retinal and Eye Research

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 247

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Boldt, K., van Reeuwijk, J., Lu, Q., Koutroumpas, K., Nguyen, T.-M. T., Texier, Y., van Beersum, S. E. C., Horn, N., Willer, J. R., Mans, D. A., et al. (2016) · Nature Communications

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 240

Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial

Fischer, M. D., Michalakis, S., Wilhelm, B., Zobor, D., Muehlfriedel, R., Kohl, S., Weisschuh, N., Ochakovski, G. A., Klein, R., Schoen, C., et al. (2020) · JAMA Ophthalmology

Retinal Development and DisordersVirus-based gene therapy research

Cited by 177

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye

Reichel, F. F., Dauletbekov, D. L., Klein, R., Peters, T., Ochakovski, G. A., Seitz, I. P., Wilhelm, B., Ueffing, M., Biel, M., Wissinger, B., et al. (2017) · Molecular Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 145

Superior retinal gene transfer and biodistribution profile of subretinal versus intravitreal delivery of AAV8 in nonhuman primates

Seitz, I. P., Michalakis, S., Wilhelm, B., Reichel, F. F., Ochakovski, G. A., Zrenner, E., Ueffing, M., Biel, M., Wissinger, B., Bartz-Schmidt, K. U., et al. (2017) · Investigative Opthalmology & Visual Science

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 108

Efficacy and Safety of Retinal Gene Therapy Using Adeno-Associated Virus Vector for Patients With Choroideremia: A Randomized Clinical Trial

Fischer, M. D., Ochakovski, G. A., Beier, B., Seitz, I. P., Vaheb, Y., Kortuem, C., Reichel, F. F. L., Kuehlewein, L., Kahle, N. A., Peters, T., et al. (2019) · JAMA Ophthalmology

Retinal Development and DisordersVirus-based gene therapy research

Cited by 92

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module

Dougherty, G. W., Mizuno, K., Nöthe-Menchen, T., Ikawa, Y., Boldt, K., Ta-Shma, A., Aprea, I., Minegishi, K., Pang, Y.-P., Pennekamp, P., et al. (2020) · Nature Communications

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 88

Humoral immune response after intravitreal but not after subretinal AAV8 in primates and patients

Reichel, F. F., Peters, T., Wilhelm, B., Biel, M., Ueffing, M., Wissinger, B., Bartz-Schmidt, K. U., Klein, R., Michalakis, S., Fischer, M. D., et al. (2018) · Investigative Opthalmology & Visual Science

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 86

Inactivation of VCP/ter94 Suppresses Retinal Pathology Caused by Misfolded Rhodopsin in Drosophila

Griciuc, A., Aron, L., Roux, M. J., Klein, R., Giangrande, A., & Ueffing, M. (2010) · PLoS Genetics

Retinal Development and DisordersEndoplasmic Reticulum Stress and Disease

Cited by 78

Dysfunction of the ciliary ARMC9/TOGARAM1 protein module causes Joubert syndrome

Latour, B. L., Van De Weghe, J. C., Rusterholz, T. D. S., Letteboer, S. J. F., Gomez, A., Shaheen, R., Gesemann, M., Karamzade, A., Asadollahi, M., Barroso-Gil, M., et al. (2020) · Journal of Clinical Investigation

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 76

Changes in Retinal Sensitivity after Gene Therapy in Choroideremia

Fischer, M. D., Ochakovski, G. A., Beier, B., Seitz, I. P., Vaheb, Y., Kortuem, C., Reichel, F. F. L., Kuehlewein, L., Kahle, N. A., Peters, T., et al. (2020) · Retina

Retinal Development and DisordersVirus-based gene therapy research

Cited by 66

HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice

Samardzija, M., Corna, A., Gomez-Sintes, R., Jarboui, M. A., Armento, A., Roger, J. E., Petridou, E., Haq, W., Paquet-Durand, F., Zrenner, E., et al. (2021) · Cell Death & Differentiation

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 48

Therapeutic targeting of the complement system in ocular disease

Rathi, S., Hasan, R., Ueffing, M., & Clark, S. J. (2023) · Drug Discovery Today

Complement system in diseasesRetinal Diseases and Treatments

Cited by 24

Ciliopathy-Associated Missense Mutations in IFT140 are Tolerated by the Inherent Resilience of the IFT Machinery

Beyer, T., Diwan, G. D., Leonhard, T., Dahlke, K., Klose, F., Stehle, I. F., Seda, M., Bolz, S., Woerz, F., Russell, R. B., et al. (2025) · Molecular & Cellular Proteomics

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 6