Engelhardt, John F.

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

Montoro, D. T., Haber, A. L., Biton, M., Vinarsky, V., Lin, B., Birket, S. E., Yuan, F., Chen, S., Leung, H. M., Villoria, J., et al. (2018) · Nature

Single-cell and spatial transcriptomicsCystic Fibrosis Research Advances

Cited by 1,206

Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

Duan, D., Sharma, P., Yang, J., Yue, Y., Dudus, L., Zhang, Y., Fisher, K. J., & Engelhardt, J. F. (1998) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 522

Lipopolysaccharide Induces Rac1-dependent Reactive Oxygen Species Formation and Coordinates Tumor Necrosis Factor-α Secretion through IKK Regulation of NF-κB

Sanlioglu, S., Williams, C. M., Samavati, L., Butler, N. S., Wang, G., McCray, P. B., Ritchie, T. C., Hunninghake, G. W., Zandi, E., & Engelhardt, J. F. (2001) · Journal of Biological Chemistry

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 395

Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus

Duan, D., Yue, Y., Yan, Z., Yang, J., & Engelhardt, J. F. (2000) · Journal of Clinical Investigation

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 391

Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy

Yan, Z., Zhang, Y., Duan, D., & Engelhardt, J. F. (2000) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 305

Expanding AAV Packaging Capacity with Trans-splicing or Overlapping Vectors: A Quantitative Comparison

Duan, D., Yue, Y., & Engelhardt, J. F. (2001) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 262

Intracellular trafficking of adeno-associated viral vectors

Ding, W., Zhang, L., Yan, Z., & Engelhardt, J. F. (2005) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 251

Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors

Lai, Y., Yue, Y., Liu, M., Ghosh, A., Engelhardt, J. F., Chamberlain, J. S., & Duan, D. (2005) · Nature Biotechnology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 224

Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors

Yan, Z., Zak, R., Luxton, G. W. G., Ritchie, T. C., Bantel-Schaal, U., & Engelhardt, J. F. (2002) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 222

Interleukin-1β Induction of NFκB Is Partially Regulated by H2O2-mediated Activation of NFκB-inducing Kinase

Li, Q., & Engelhardt, J. F. (2006) · Journal of Biological Chemistry

NF-κB Signaling PathwaysRedox biology and oxidative stress

Cited by 219

A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation

Duan, D., Yue, Y., Yan, Z., & Engelhardt, J. F. (2000) · Nature Medicine

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 200

Signaling Role of Intracellular Iron in NF-κB Activation

Xiong, S., She, H., Takeuchi, H., Han, B., Engelhardt, J. F., Barton, C. H., Zandi, E., Giulivi, C., & Tsukamoto, H. (2003) · Journal of Biological Chemistry

NF-κB Signaling PathwaysIron Metabolism and Disorders

Cited by 161

Redox modifier genes in amyotrophic lateral sclerosis in mice

Marden, J. J., Harraz, M. M., Williams, A. J., Nelson, K., Luo, M., Paulson, H., & Engelhardt, J. F. (2007) · Journal of Clinical Investigation

Amyotrophic Lateral Sclerosis ResearchRedox biology and oxidative stress

Cited by 145

Distinct Classes of Proteasome-Modulating Agents Cooperatively Augment Recombinant Adeno-Associated Virus Type 2 and Type 5-Mediated Transduction from the Apical Surfaces of Human Airway Epithelia

Yan, Z., Zak, R., Zhang, Y., Ding, W., Godwin, S., Munson, K., Peluso, R., & Engelhardt, J. F. (2004) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 138

Inverted terminal repeat sequences are important for intermolecular recombination and circularization of adeno-associated virus genomes

Yan, Z., Zak, R., Zhang, Y., & Engelhardt, J. F. (2005) · Journal of Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 107

Structural Analysis of Adeno-Associated Virus Transduction Circular Intermediates

Duan, D., Yan, Z., Yue, Y., & Engelhardt, J. F. (1999) · Virology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 100

Hybrid Adeno-Associated Virus Bearing Nonhomologous Inverted Terminal Repeats Enhances Dual-Vector Reconstruction of Minigenes In Vivo

Yan, Z., Lei-Butters, D. C. M., Zhang, Y., Zak, R., & Engelhardt, J. F. (2007) · Human Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 41

Cystic Fibrosis-Related Diabetes Workshop: research priorities spanning disease pathophysiology, diagnosis, and outcomes

Putman, M. S., Norris, A. W., Hull, R. L., Rickels, M. R., Sussel, L., Blackman, S. M., Chan, C. L., Ode, K. L., Daley, T., Stecenko, A. A., et al. (2023) · Diabetes Care

Cystic Fibrosis Research AdvancesPancreatic function and diabetes

Cited by 35

Dual Vector Expansion of the Recombinant AAV Packaging Capacity

Duan, D., Yue, Y., & Engelhardt, J. F. (2003) · Cardiac Cell and Gene Transfer

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 26

Repeat dosing of AAV2. 5T to ferret lungs elicits an antibody response that diminishes transduction in an age-dependent manner

Tang, Y., Yan, Z., Lin, S., Huntemann, E. D., Feng, Z., Park, S.-Y., Sun, X., Yuen, E., & Engelhardt, J. F. (2020) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 21

Trans-Splicing Vectors Expand the Packaging Limits of Adeno-Associated Virus for Gene Therapy Applications

Duan, D., Yue, Y., Yan, Z., & Engelhardt, J. F. (2003) · Viral Vectors for Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 16