Holt, Jeffrey R.

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

Gao, X., Tao, Y., Lamas, V., Huang, M., Yeh, W.-H., Pan, B., Hu, Y.-J., Hu, J. H., Thompson, D. B., Shu, Y., et al. (2018) · Nature

Hearing, Cochlea, Tinnitus, GeneticsCRISPR and Genetic Engineering

Cited by 536

Continuous evolution of base editors with expanded target compatibility and improved activity

Thuronyi, B. W., Koblan, L. W., Levy, J. M., Yeh, W.-H., Zheng, C., Newby, G. A., Wilson, C., Bhaumik, M., Shubina-Oleinik, O., Holt, J. R., et al. (2019) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 347

Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells

Koehler, K. R., Nie, J., Longworth-Mills, E., Liu, X.-P., Lee, J., Holt, J. R., & Hashino, E. (2017) · Nature Biotechnology

Hearing, Cochlea, Tinnitus, GeneticsPluripotent Stem Cells Research

Cited by 341

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

Landegger, L. D., Pan, B., Askew, C., Wassmer, S. J., Gluck, S. D., Galvin, A., Taylor, R., Forge, A., Stankovic, K. M., Holt, J. R., et al. (2017) · Nature Biotechnology

Virus-based gene therapy researchHearing, Cochlea, Tinnitus, Genetics

Cited by 325

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Giese, A. P., Weng, W.-H., Kindt, K. S., Chang, H. H. V., Montgomery, J. S., Ratzan, E. M., Beirl, A. J., Aponte Rivera, R., Lotthammer, J. M., Walujkar, S., et al. (2025) · eLife

Hearing, Cochlea, Tinnitus, GeneticsIon Channels and Receptors

Cited by 8

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Giese, A. P. J., Weng, W.-H., Kindt, K. S., Chang, H. H. V., Montgomery, J. S., Ratzan, E. M., Beirl, A. J., Rivera, R. A., Lotthammer, J. M., Walujkar, S., et al. (2023) · eLife

Hearing, Cochlea, Tinnitus, GeneticsIon Channels and Receptors

Cited by 8