Adam, Julie

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

Adam, J., Hatipoglu, E., O'Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban, D., Nye, E., Stamp, G. W., Wolhuter, K., et al. (2011) · Cancer Cell

Genomics, phytochemicals, and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 585

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

Frezza, C., Zheng, L., Folger, O., Rajagopalan, K. N., MacKenzie, E. D., Jerby, L., Micaroni, M., Chaneton, B., Adam, J., Hedley, A., et al. (2011) · Nature

Cancer, Hypoxia, and MetabolismHeme Oxygenase-1 and Carbon Monoxide

Cited by 503

Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status

Bardella, C., El‐Bahrawy, M., Frizzell, N., Adam, J., Ternette, N., Hatipoglu, E., Howarth, K., O'Flaherty, L., Roberts, I., Turner, G., et al. (2011) · The Journal of Pathology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 281

The emerging role of fumarate as an oncometabolite

Yang, M., Soga, T., Pollard, P. J., & Adam, J. (2012) · Frontiers in Oncology

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 189

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency

Ternette, N., Yang, M., Laroyia, M., Kitagawa, M., O’Flaherty, L., Wolhulter, K., Igarashi, K., Saito, K., Kato, K., Fischer, R., et al. (2013) · Cell Reports

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 158

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Vergari, E., Knudsen, J. G., Ramracheya, R., Salehi, A., Zhang, Q., Adam, J., Asterholm, I. W., Benrick, A., Briant, L. J. B., Chibalina, M. V., et al. (2019) · Nature Communications

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 152

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia

Adam, J., Yang, M., Bauerschmidt, C., Kitagawa, M., O’Flaherty, L., Maheswaran, P., Özkan, G., Sahgal, N., Baban, D., Kato, K., et al. (2013) · Cell Reports

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 97

Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells

Vergari, E., Denwood, G., Salehi, A., Zhang, Q., Adam, J., Alrifaiy, A., Wernstedt Asterholm, I., Benrick, A., Chibalina, M. V., Eliasson, L., et al. (2020) · Nature Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 43

Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism

Bardella, C., Olivero, M., Lorenzato, A., Geuna, M., Adam, J., O'Flaherty, L., Rustin, P., Tomlinson, I., Pollard, P. J., & Di Renzo, M. F. (2012) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 33