Kelley, Robert F.

A strategy for risk mitigation of antibodies with fast clearance

Hötzel, I., Theil, F.-P., Bernstein, L. J., Prabhu, S., Deng, R., Quintana, L., Lutman, J., Sibia, R., Chan, P., Bumbaca, D., et al. (2012) · mAbs

Monoclonal and Polyclonal Antibodies ResearchProtein purification and stability

Cited by 245

Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab

Ultsch, M., Bevers, J., Nakamura, G., Vandlen, R., Kelley, R. F., Wu, L. C., & Eigenbrot, C. (2013) · Journal of Molecular Biology

Cytokine Signaling Pathways and InteractionsMonoclonal and Polyclonal Antibodies Research

Cited by 174

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys

Leabman, M. K., Meng, Y. G., Kelley, R. F., DeForge, L. E., Cowan, K. J., & Iyer, S. (2013) · mAbs

Monoclonal and Polyclonal Antibodies ResearchProtein purification and stability

Cited by 110

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics

Bumbaca Yadav, D., Sharma, V. K., Boswell, C. A., Hotzel, I., Tesar, D., Shang, Y., Ying, Y., Fischer, S. K., Grogan, J. L., Chiang, E. Y., et al. (2015) · Journal of Biological Chemistry

Monoclonal and Polyclonal Antibodies ResearchBiosimilars and Bioanalytical Methods

Cited by 82

Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates

Dostalek, M., Prueksaritanont, T., & Kelley, R. F. (2017) · mAbs

Monoclonal and Polyclonal Antibodies ResearchBiosimilars and Bioanalytical Methods

Cited by 45

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation

Li, B., Fouts, A. E., Stengel, K., Luan, P., Dillon, M., Liang, W.-C., Feierbach, B., Kelley, R. F., & Hötzel, I. (2014) · mAbs

Monoclonal and Polyclonal Antibodies ResearchProtein purification and stability

Cited by 28

Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation

Gong, Q., Hazen, M., Marshall, B., Crowell, S. R., Ou, Q., Wong, A. W., Phung, W., Vernes, J.-M., Meng, Y. G., Tejada, M., et al. (2016) · mAbs

Monoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins Research

Cited by 26