Jacobs, Jacqueline J.L.

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 1,580

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

Itahana, K., Zou, Y., Itahana, Y., Martinez, J.-L., Beausejour, C., Jacobs, J. J. L., van Lohuizen, M., Band, V., Campisi, J., & Dimri, G. P. (2003) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 438

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers

Jacobs, J. J. L., Keblusek, P., Robanus-Maandag, E., Kristel, P., Lingbeek, M., Nederlof, P. M., van Welsem, T., van de Vijver, M. J., Koh, E. Y., Daley, G. Q., et al. (2000) · Nature Genetics

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 368

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

Bruggeman, S. W. M., Valk-Lingbeek, M. E., van der Stoop, P. P. M., Jacobs, J. J. L., Kieboom, K., Tanger, E., Hulsman, D., Leung, C., Arsenijevic, Y., Marino, S., et al. (2005) · Genes & Development

Epigenetics and DNA MethylationCancer-related Molecular Pathways

Cited by 315

Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence

Jacobs, J. J. L., & de Lange, T. (2004) · Current Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 237

The T-box Repressors TBX2 and TBX3Specifically Regulate the Tumor Suppressor Genep14 via a Variant T-site in the Initiator

Lingbeek, M. E., Jacobs, J. J. L., & van Lohuizen, M. (2002) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 160