Pandey, Amit V.

Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome

Flück, C. E., Tajima, T., Pandey, A. V., Arlt, W., Okuhara, K., Verge, C. F., Jabs, E. W., Mendonça, B. B., Fujieda, K., & Miller, W. L. (2004) · Nature Genetics

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 509

Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis

Huang, N., Pandey, A. V., Agrawal, V., Reardon, W., Lapunzina, P. D., Mowat, D., Jabs, E. W., Vliet, G. V., Sack, J., Flück, C. E., et al. (2005) · The American Journal of Human Genetics

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 336

NADPH P450 oxidoreductase: Structure, function, and pathology of diseases

Pandey, A. V., & Flück, C. E. (2013) · Pharmacology & Therapeutics

Pharmacogenetics and Drug MetabolismMetabolism and Genetic Disorders

Cited by 279

Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation

Flück, C. E., Meyer-Böni, M., Pandey, A. V., Kempná, P., Miller, W. L., Schoenle, E. J., & Biason-Lauber, A. (2011) · The American Journal of Human Genetics

Sexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Cited by 248

Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17

Pandey, A. V., & Miller, W. L. (2005) · Journal of Biological Chemistry

Adrenal Hormones and DisordersSteroid Chemistry and Biochemistry

Cited by 165

Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17

Pandey, A. V., Mellon, S. H., & Miller, W. L. (2003) · Journal of Biological Chemistry

Adrenal Hormones and DisordersHormonal Regulation and Hypertension

Cited by 137

Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase

Pandey, A. V., Kempná, P., Hofer, G., Mullis, P. E., & Flück, C. E. (2007) · Molecular Endocrinology

Pharmacogenetics and Drug MetabolismAdrenal Hormones and Disorders

Cited by 132

Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia

Flück, C. E., Pandey, A. V., Dick, B., Camats, N., Fernández-Cancio, M., Clemente, M., Gussinyé, M., Carrascosa, A., Mullis, P. E., & Audi, L. (2011) · PLoS ONE

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 94

Pharmacogenomics of human P450 oxidoreductase

Pandey, A. V., & Sproll, P. (2014) · Frontiers in Pharmacology

Pharmacogenetics and Drug MetabolismSexual Differentiation and Disorders

Cited by 92

P450 Oxidoreductase deficiency: Analysis of mutations and polymorphisms

Burkhard, F. Z., Parween, S., Udhane, S. S., Flück, C. E., & Pandey, A. V. (2017) · The Journal of Steroid Biochemistry and Molecular Biology

Pharmacogenetics and Drug MetabolismSexual Differentiation and Disorders

Cited by 79

Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome

Marti, N., Galván, J. A., Pandey, A. V., Trippel, M., Tapia, C., Müller, M., Perren, A., & Flück, C. E. (2017) · Molecular and Cellular Endocrinology

Ovarian function and disordersSexual Differentiation and Disorders

Cited by 76

Of marsupials and men: “Backdoor” dihydrotestosterone synthesis in male sexual differentiation

Biason-Lauber, A., Miller, W. L., Pandey, A. V., & Flück, C. E. (2013) · Molecular and Cellular Endocrinology

Sexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Cited by 69

Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, C. C., Thomsen, J., Sletfjerding, M. B., Knudsen, C., Del Giudice, R., Lund, P. M., et al. (2021) · Nature Communications

Metal-Catalyzed Oxygenation MechanismsPharmacogenetics and Drug Metabolism

Cited by 64

Reduction in hepatic drug metabolizing CYP3A4 activities caused by P450 oxidoreductase mutations identified in patients with disordered steroid metabolism

Flück, C. E., Mullis, P. E., & Pandey, A. V. (2010) · Biochemical and Biophysical Research Communications

Pharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 59

Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H

Parween, S., DiNardo, G., Baj, F., Zhang, C., Gilardi, G., & Pandey, A. V. (2020) · The Journal of Steroid Biochemistry and Molecular Biology

Pharmacogenetics and Drug MetabolismSexual Differentiation and Disorders

Cited by 39

Altered CYP19A1 and CYP3A4 Activities Due to Mutations A115V, T142A, Q153R and P284L in the Human P450 Oxidoreductase

Udhane, S. S., Parween, S., Kagawa, N., & Pandey, A. V. (2017) · Frontiers in Pharmacology

Pharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 38

P450 Oxidoreductase Deficiency: Loss of Activity Caused by Protein Instability From a Novel L374H Mutation

Parween, S., Roucher-Boulez, F., Flück, C. E., Lienhardt-Roussie, A., Mallet, D., Morel, Y., & Pandey, A. V. (2016) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 37

P450 oxidoreductase deficiency

Miller, W. L., Huang, N., Flück, C. E., & Pandey, A. V. (2004) · The Lancet

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 37

Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase

Pandey, A. V., Flück, C. E., & Mullis, P. E. (2010) · Biochemical and Biophysical Research Communications

Heme Oxygenase-1 and Carbon MonoxideNeonatal Health and Biochemistry

Cited by 36

Disordered Electron Transfer: New Forms of Defective Steroidogenesis and Mitochondriopathy

Miller, W. L., Pandey, A. V., & Flück, C. E. (2025) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersMetabolism and Genetic Disorders

Cited by 17

Inhibition of placental CYP19A1 activity remains as a valid hypothesis for 46,XX virilization in P450 oxidoreductase deficiency

Flück, C. E., Parween, S., Rojas Velazquez, M. N., & Pandey, A. V. (2020) · Proceedings of the National Academy of Sciences

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 15

FDXR variants cause adrenal insufficiency and atypical sexual development

Pignatti, E., Slone, J., Gómez Cano, M. Á., Campbell, T. M., Vu, J., Sauter, K.-S., Pandey, A. V., Martínez-Azorín, F., Alonso-Riaño, M., Neilson, D. E., et al. (2024) · JCI Insight

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 12

Loss of Protein Stability and Function Caused by P228L Variation in NADPH-Cytochrome P450 Reductase Linked to Lower Testosterone Levels

Rojas Velazquez, M. N., Noebauer, M., & Pandey, A. V. (2022) · International Journal of Molecular Sciences

Pharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 11