Lismont, Sam

The mechanism of γ‐Secretase dysfunction in familial Alzheimer disease

Chávez‐Gutiérrez, L., Bammens, L., Benilova, I., Vandersteen, A., Benurwar, M., Borgers, M., Lismont, S., Zhou, L., Van Cleynenbreugel, S., Esselmann, H., et al. (2012) · The EMBO Journal

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 495

Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions

Szaruga, M., Munteanu, B., Lismont, S., Veugelen, S., Horré, K., Mercken, M., Saido, T. C., Ryan, N. S., De Vos, T., Savvides, S. N., et al. (2017) · Cell

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 248

Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease

Szaruga, M., Veugelen, S., Benurwar, M., Lismont, S., Sepulveda-Falla, D., Lleo, A., Ryan, N. S., Lashley, T., Fox, N. C., Murayama, S., et al. (2015) · Journal of Experimental Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 155

Structure of γ-secretase (PSEN1/APH-1B) in complex with Aβ46 provides insights into amyloid-β processing and modulation by the APH-1B isoform

Odorcic, I., Hamed Soliman, M. B., Lismont, S., Chávez-Gutiérrez, L., & Efremov, R. G. (2023) · Nature Communications

Alzheimer's disease research and treatmentsEnzyme Structure and Function

Cited by 15

Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform

Odorčić, I., Hamed, M. B., Lismont, S., Chávez-Gutiérrez, L., & Efremov, R. G. (2024) · Nature Communications

Alzheimer's disease research and treatmentsEnzyme Structure and Function

Cited by 15